Dexmedetomidin is a new-generation, highly selective α2 adrenergic receptor agonist with a
large number of advantages, including its sedative and analgesic properties, its ability to …

Tramadol—an atypical opioid analgesic—has a unique pharmacokinetic and
pharmacodynamic profile, with opioidergic, noradrenergic, and serotonergic actions …

The effective treatment of patients suffering from neuropathic pain remains challenging.
Dexmedetomidine (DEX) possesses anti-inflammatory activity. However, the role of DEX in …

Given that patients with neuropathic pain suffer a mixture of spontaneous and evoked pain
symptoms, we assessed the effects of drugs with different mechanism of action on …

Dexmedetomidine (Dex) is a novel Alpha 2-adrenoceptor agonist. It decreases sympathetic
tone and attenuates the stress responses to anesthesia and surgery. People exposed to …

Background The pain-relief properties of tricyclic antidepressants can be attributed to
several actions. Recent observations suggest that adenosine is involved in the …

Background: Pulsed radiofrequency (PRF) is increasingly used in clinical practice,
especially in neuropathic pain disorders. Although PRF is not new to clinical use, there are …

Abstract Preclinical Research The current work evaluates the interaction between two
commonly used drugs, tramadol (Tra) and gabapentin (Gbp). Dose‐response curves (DRC) …

Although drugs such as acetaminophen, opioids, and nonsteroidal anti-inflammatory drugs
(NSAIDs), are commonly used for pain management, the side effects of these drugs such as …

Diabetic peripheral neuropathy (DPN) is a common chronic complication of diabetes.
Jinmaitong (JMT), a Traditional Chinese Medicine, improves certain symptoms of DPN, such …