Multiphoton fluorescence microscopy (MPFM) has been a game-changer for optical
imaging, particularly for studying biological tissues deep within living organisms. MPFM …

The brain is a remarkably capable and efficient system. It can process and store huge
amounts of noisy and unstructured information, using minimal energy. In contrast, current …

During neuronal activity, the extracellular concentration of potassium ions ([K+] o) increases
substantially above resting levels, yet it remains unclear what role these [K+] o changes play …

Neurons integrate synaptic inputs within their dendrites and produce spiking outputs, which
then propagate down the axon and back into the dendrites where they contribute to …

Abstract Theory predicts that nonlinear summation of synaptic potentials within dendrites
allows neurons to perform linearly non-separable computations (LNSCs). Using Boolean …

Glutamatergic synapses are the primary site of excitatory synaptic signaling and neural
communication in the cerebral cortex. Electron microscopy (EM) studies in non-human …

Hippocampal pyramidal neurons support episodic memory by integrating complementary
information streams into new 'place fields'. Distal tuft dendrites are thought to initiate place …

Intractable epilepsy and cognitive deficits arise from missense variants in GRIN genes
encoding subunits of the N-Methyl-D-Aspartate receptor (NMDAR). Here, we go beyond …

Hippocampal pyramidal neurons support episodic memory by integrating complementary
information streams into new 'place fields'. Distal tuft dendrites are widely thought to initiate …

Dendrites are root-like extensions from the neuron cell body and have long been thought to
serve as the predominant input structures of neurons. Since the early twentieth century …