The seven-transmembrane G protein-coupled receptors activated by leukotrienes are
divided into two subclasses based on their ligand specificity for either leukotriene B4 or the …

Leukotrienes are pro-inflammatory lipid mediators, which are biosynthesized via the
lipoxygenase pathway of the arachidonic acid cascade. Lipoxygenases form a family of lipid …

Adverse drug reactions (ADRs) result in major health problems in the United States in both
the inpatient and outpatient setting. ADRs are broadly categorized into predictable (type A …

Eicosanoids are biologically active lipid mediators, comprising prostaglandins, leukotrienes,
thromboxanes, and lipoxins, involved in several pathophysiological processes relevant to …

There are over 100 genes that have been reported to be associated with asthma or related
phenotypes. In 2006–2007 alone there were 53 novel candidate gene associations reported …

A Karger'Publishing Highlights 1890-2015'title Drug hypersensitivities are immune-mediated
reactions characterized by exanthems, fever and internal organ involvement. They represent …

Leukotrienes (LT) are biologically active lipid mediators known to be involved in allergic
inflammation. Leukotrienes have been shown to mediate diverse features of allergic …

Aspirin-exacerbated respiratory disease (AERD) is characterized by the quatrad of asthma,
eosinophilic rhinosinusitis, nasal polyposis, and the onset of respiratory reactions after …

Off‐target adverse drug reactions (ADRs) are associated with significant morbidity and costs
to the healthcare system, and their occurrence is not predictable based on the known …

The advent of targeted therapies for asthma and clinical trials based on phenotype and
genotype have raised interest in more accurate description of asthma phenotypes …