Organophosphates (OPs) are an integral part of modern agriculture; however, due to
overexploitation, OPs pesticides residues are leaching and accumulating in the soil, and …

Organophosphates are one of the major constituent of herbicides, pesticides, insecticides
and nerve gas. Azinophos-methyl, chlorpyrifos, diazinon, fonofos and disulfoton are well …

Upon heterologous overexpression, many proteins misfold or aggregate, thus resulting in
low functional yields. Human acetylcholinesterase (hAChE), an enzyme mediating synaptic …

Two decades ago, theoretical model calculations played a truly minor role in understanding
mechanisms of redox-active metalloenzymes. The methods available to treat transition …

Synthetic organophosphorus compounds are used as pesticides, plasticizers, air fuel
ingredients and chemical warfare agents. Organophosphorus compounds are the most …

While recognizing the gaps in pesticide regulations that impact consumer safety, public
health concerns associated with pesticide contamination of foods are pointed out. The …

This Overview describes the general concepts behind the quantum chemical cluster
approach for modeling enzyme active sites and reaction mechanisms. First, the underlying …

The amidohydrolase superfamily comprises a remarkable set of enzymes that catalyze the
hydrolysis of a wide range of substrates bearing amide or ester functional groups at carbon …

Phosphotriesters are one class of highly toxic synthetic compounds known as
organophosphates. Wide spread usage of organophosphates as insecticides as well as …

Phosphotriesterase (PTE) from Pseudomonas diminuta is a zinc metalloenzyme that
hydrolyzes a variety of organophosphorus compounds. The kinetic parameters of Zn/Zn …