Alzheimer's disease (AD) is a progressive neurodegenerative disease, characterized by the
loss of memory, multiple cognitive impairments and changes in the personality and …

None of the proposed mechanisms of Alzheimer's disease (AD) fully explains the distribution
patterns of the neuropathological changes at the cellular and regional levels, and their …

Among the four G protein–coupled receptors (H1–H4) identified as mediators of the biologic
effects of histamine, the H3 receptor (H3R) is distinguished for its almost exclusive …

Brain “fog” is a constellation of symptoms that include reduced cognition, inability to
concentrate and multitask, as well as loss of short and long term memory. Brain “fog” …

Histamine is a conserved neuromodulator in mammalian brains and critically involved in
many physiological functions. Understanding the precise structure of the histaminergic …

Norepinephrine (NE) is synthesized in the Locus Coeruleus (LC) of the brainstem, from
where it is released by axonal varicosities throughout the brain via volume transmission. A …

Study objective To assess comorbidities in a community-based cohort of narcolepsy.
Methods A 2000–2014 community-based narcolepsy cohort was identified in Olmsted …

The neurotransmitter histamine receives less attention compared with other biogenic
amines, because of its moderate action in the central nervous system (CNS). However …

Neurotransmitters are considered as a fundamental regulator in the process of neuronal
growth, differentiation and survival. Parkinson's Disease (PD) occurs due to extensive …

The biogenic amine, histamine, has been shown to critically modulate inflammatory
processes as well as the properties of neurons and synapses in the brain, and is also …