Adherens junctions (AJs) are molecular complexes that mediate cell-cell adhesive
interactions and play pivotal roles in maintenance of tissue organization in adult organisms …

Epithelial cell–cell junctions are formed by apical adherens junctions (AJs), which are
composed of cadherin adhesion molecules interacting in a dynamic way with the cortical …

Cadherin-mediated adhesion initiates cell reorganization into tissues, but the mechanisms
and dynamics of such adhesion are poorly understood. Using time-lapse imaging and …

To enable stratification and barrier function, the epidermis must permit self-renewal while
maintaining adhesive connections. By generating K14-GFP-actin mice to monitor actin …

We present a three-dimensional individual cell-based, biophysical model to study the effect
of normal and malfunctioning growth regulation and control on the spatial-temporal …

The motile behavior of epithelial cells located at the edge of a large wound in a monolayer of
cultured cells was analyzed. The initial cellular response is alignment of the edge with an …

The movement of a metazoan cell entails the regulated creation and turnover of adhesions
with the surface on which it moves. Adhesion sites form as a result of signaling between the …

How adherens junctions (AJs) are formed upon cell division is largely unexplored. Here, we
found that AJ formation is coordinated with cytokinesis and relies on an interplay between …

Cadherin-mediated adhesion regulates transitions from initial cell—cell recognition to
loosely adherent cell clusters and ultimately, to strongly compacted groups of cells in …

Tumor progression involves the transition from normal to malignant cells, through a series of
cumulative alterations. During this process, invasive and migratory properties are acquired …