[HTML][HTML] Small-molecule RAS inhibitors as anticancer agents: discovery, development, and mechanistic studies

SA Shetu, D Bandyopadhyay - International Journal of Molecular …, 2022 - mdpi.com
Mutations of RAS oncogenes are responsible for about 30% of all human cancer types,
including pancreatic, lung, and colorectal cancers. While KRAS1 is a pseudogene, mutation …

[HTML][HTML] Natural products attenuating biosynthesis, processing, and activity of ras oncoproteins: state of the art and future perspectives

R Tisi, V Gaponenko, M Vanoni, E Sacco - Biomolecules, 2020 - mdpi.com
RAS genes encode signaling proteins, which, in mammalian cells, act as molecular switches
regulating critical cellular processes as proliferation, growth, differentiation, survival, motility …

[HTML][HTML] TMEM9 promotes lung adenocarcinoma progression via activating the MEK/ERK/STAT3 pathway to induce VEGF expression

Z Wang, P Zhao, K Tian, Z Qiao, H Dong, J Li… - Cell Death & …, 2024 - nature.com
Abstract Abnormal Transmembrane protein 9 (TMEM9) expression has been identified in
various human tumors. However, the prognostic potential and mechanistic role of TMEM9 in …

[HTML][HTML] Analysis of Marker Compounds in Lindera erythrocarpa from Diverse Geographical Regions of Korea

NP Uy, JH Kim, DY Kim, J Ku, S Lee - Separations, 2024 - mdpi.com
Lindera erythrocarpa M., a medicinal plant commonly found in China, Japan, and Korea, is
well known for its antioxidant, anti-inflammatory, and potential anti-cancer effects. However …

Preliminary investigation on the mechanism of baicalein regulating the effects of Nischarin on invasion and apoptosis of human breast cancer cells MCF-7 through …

G He, X Huang, Y Dong, K Chen, X He, M Pan… - International …, 2024 - Elsevier
Background Breast cancer (BC) remains the leading cause of cancer-related mortality in
women. Here, we investigate the anti-tumor effects of baicalein on human BC cells (MCF-7 …

Screening of plant collection of Cibodas Botanic Gardens, Indonesia with anticancer properties

R Pratiwi, Y Nurlaeni - Biodiversitas Journal Of Biological Diversity, 2020 - smujo.id
Pratiwi RA, Nurlaeni Y. 2020. Screening of plant collection of Cibodas Botanic Gardens,
Indonesia with anticancer properties. Biodiversitas 21: 5186-5229. Cancer is a life …

[HTML][HTML] Miconazole suppresses 27-hydroxycholesterol-induced inflammation by regulating activation of monocytic cells to a proinflammatory phenotype

BY Kim, Y Son, H Cho, D Lee, SK Eo… - Frontiers in …, 2021 - frontiersin.org
Miconazole is effective in treating inflammatory skin conditions and has well-established
antifungal effects. To elucidate the underlying mechanisms mediating its additional …

The enzymes of serine synthesis pathway in cancer metastasis

L Li, Y Qin, Y Chen - Biochimica et Biophysica Acta (BBA)-Molecular Cell …, 2024 - Elsevier
Metastasis, the major cause of cancer mortality, requires cancer cells to reprogram their
metabolism to adapt to and thrive in different environments, thereby leaving metastatic cells …

[PDF][PDF] 槐耳浸膏通过调控ROS 抑制结直肠癌细胞MMP-9 表达及侵袭能力的研究

谢海娟, 王毓兴, 张丽君, 龙文清… - 中国中西医结合消化 …, 2021 - zxyxhen.whuhzzs.com
目的: 探讨槐耳浸膏对结直肠癌细胞活性氧(ROS) 的调控作用及细胞侵袭能力的影响. 方法:
利用PKC 激动剂佛波酯(TPA) 处理人结直肠癌SW480 细胞, 倒置显微镜下观察TPA …

[HTML][HTML] Kanakugiol, a compound isolated from Lindera erythrocarpa, promotes cell death by inducing mitotic catastrophe after cell cycle arrest

J Lee, HW Chun, TH Pham, JH Yoon… - … of Microbiology and …, 2020 - ncbi.nlm.nih.gov
A novel compound named 'kanakugiol'was recently isolated from Lindera erythrocarpa and
showed free radical-scavenging and antifungal activities. However, the details of the …