Oligomeric state and drug binding of the SARS-CoV-2 envelope protein are sensitive to the ectodomain

NH Somberg, I Sučec, J Medeiros-Silva… - Journal of the …, 2024 - ACS Publications
The envelope (E) protein of SARS-CoV-2 is the smallest of the three structural membrane
proteins of the virus. E mediates budding of the progeny virus in the endoplasmic reticulum …

Conformational heterogeneity and structural features for function of the prototype viroporin influenza AM2

K Georgiou, A Kolocouris - Biochimica et Biophysica Acta (BBA) …, 2024 - Elsevier
The 97-residue influenza A matrix 2 (ΑM2) protein, a prototype for viroporins, transports
protons through water molecules and His37. We discuss structural biology and molecular …

Dimeric transmembrane structure of the SARS-CoV-2 E protein

R Zhang, H Qin, R Prasad, R Fu, HX Zhou… - Communications …, 2023 - nature.com
Abstract The SARS-CoV-2 E protein is a transmembrane (TM) protein with its N-terminus
exposed on the external surface of the virus. At debate is its oligomeric state, let alone its …

[HTML][HTML] Membrane Activity and Viroporin Assembly for the SARS-CoV-2 E Protein Are Regulated by Cholesterol

MV Volovik, ZG Denieva, PK Gifer, MA Rakitina… - Biomolecules, 2024 - mdpi.com
The SARS-CoV-2 E protein is an enigmatic viral structural protein with reported viroporin
activity associated with the acute respiratory symptoms of COVID-19, as well as the ability to …

[HTML][HTML] Highly versatile small virus-encoded proteins in cellular membranes: A structural perspective on how proteins' inherent conformational plasticity couples with …

AS Delkhosh, E Hadadianpour, MM Islam… - Journal of Structural …, 2024 - Elsevier
We investigated several small viral proteins that reside and function in cellular membranes.
These proteins belong to the viroporin family because they assemble into ion-conducting …

Preclinical evaluation of a cross-protective ß-SARS-CoV-2 virus-like particle vaccine adjuvanted with MF59

J Torresi, L Earnest, D Ruiz, M Edeling, J Montoya… - 2024 - researchsquare.com
Background: The COVID-19 pandemic led to the development of many vaccines, most
notably the mRNA and recombinant adenoviral vaccines. Whilst the vaccines proved to be …