New insights into the correlations between circulating tumor cells and target organ metastasis

Q Zhan, B Liu, X Situ, Y Luo, T Fu, Y Wang… - … and Targeted Therapy, 2023 - nature.com
Organ-specific metastasis is the primary cause of cancer patient death. The distant
metastasis of tumor cells to specific organs depends on both the intrinsic characteristics of …

Micro-magnetofluidic system for rare cell analysis: from principle to translation

K Chen, Z Wang - Chemosensors, 2023 - mdpi.com
Rare cells play essential roles in the initiation and progression of diseases and therefore
their analysis is of great interest. The micro-magnetofluidic system is one of the emerging …

Polyploid cancer cells reveal signatures of chemotherapy resistance

MJ Schmidt, A Naghdloo, RK Prabakar, M Kamal… - Oncogene, 2024 - nature.com
Therapeutic resistance in cancer significantly contributes to mortality, with many patients
eventually experiencing recurrence after initial treatment responses. Recent studies have …

Cells in the polyaneuploid cancer cell (PACC) state have increased metastatic potential

MM Mallin, N Kim, MI Choudhury, SJ Lee… - Clinical & Experimental …, 2023 - Springer
Although metastasis is the leading cause of cancer deaths, it is quite rare at the cellular
level. Only a rare subset of cancer cells (~ 1 in 1.5 billion) can complete the entire metastatic …

Cancer-related cells and oncosomes in the liquid biopsy of pancreatic cancer patients undergoing surgery

SN Shishido, E Lin, N Nissen, G Courcoubetis… - npj Precision …, 2024 - nature.com
Pancreatic ductal adenocarcinoma (PDAC) has a five-year survival rate of less than 10%
due to its late diagnosis, rapid metastasis, and chemotherapeutic resistance. For a small …

Investigation of liquid biopsy analytes in peripheral blood of individuals after SARS-CoV-2 infection

E Qi, G Courcoubetis, E Liljegren, E Herrera… - …, 2023 - thelancet.com
Background Post-acute COVID-19 syndrome (PACS) is linked to severe organ damage. The
identification and stratification of at-risk SARS-CoV-2 infected individuals is vital to providing …

[HTML][HTML] Resolving tumor evolution: a phylogenetic approach

L Li, W Xie, L Zhan, S Wen, X Luo, S Xu, Y Cai… - Journal of the National …, 2024 - Elsevier
The evolutionary dynamics of cancer, characterized by its profound heterogeneity, demand
sophisticated tools for a holistic understanding. This review delves into tumor phylogenetics …

Determining the efficacy of ExThera Seraph100 blood filtration in patients diagnosed with pancreatic cancer through the liquid biopsy

SN Shishido, D Suresh, G Courcoubetis, B Ye, E Lin… - BJC reports, 2024 - nature.com
Background Cancer becomes lethal as it spreads from the primary site to the rest of the
body. Circulating tumor cells (CTCs) are biomarkers of disease progression and have been …

[HTML][HTML] Multi-Omic Characterization of Single Cells and Cell-Free Components Detected in the Cerebrospinal Fluid of Patients with Leptomeningeal Disease

SN Shishido, A Marvit, D Pham, T Luo, L Xu, J Mason… - Cancers, 2024 - mdpi.com
Abstract Background/Objectives: Up to 30% of patients with breast cancers will develop
brain or leptomeningeal metastases, and this risk is especially high with HER2-positive …

Circulation of rare events in the liquid biopsy for early detection of lung mass lesions

K Resnick, A Shah, J Mason, P Kuhn, J Nieva… - Thoracic …, 2024 - Wiley Online Library
Background Lung cancer screening with low‐dose computed tomography (CT) scans
(LDCT) has reduced mortality for patients with high‐risk smoking histories, but it has …