Background Genetic testing for risk of hereditary cancer can help patients to make important
decisions about prevention or early detection. US and UK studies show that people from …

Background: Mutations in breast cancer susceptibility genes (BRCA1 and BRCA2) are
associated with increased risks for breast, ovarian, and other types of cancer. Purpose: To …

The prevalence and spectrum of germline mutations in BRCA1 and BRCA2 have been
reported in single populations, with the majority of reports focused on White in Europe and …

Non-communicable diseases, including cancer, are overtaking infectious disease as the
leading health-care threat in middle-income and low-income countries. Latin American and …

Breast cancer is the most commonly diagnosed cancer worldwide and is one of the leading
causes of cancer death. The incidence, pathological features, and clinical outcomes in …

Germline mutations in the BRCA1 or BRCA2 tumour-suppressor genes are strong predictors
of breast and/or ovarian cancer development. The contribution of these mutations to breast …

BACKGROUND: In women at increased risk for breast and ovarian cancer, the identification
of a mutation in breast cancer gene 1 (BRCA1) and BRCA2 has important implications for …

ContextInformation on the prevalence of pathogenic BRCA1 mutation carriers in
racial/ethnic minority populations is limited. ObjectiveTo estimate BRCA1 carrier prevalence …

BRCA1 and BRCA2 germline mutations contribute to a significant number of familial and
hereditary breast and/or ovarian cancers. The proportion of high-risk families with breast …

Purpose Women with early-onset (age≤ 40 years) breast cancer are at high risk of carrying
deleterious mutations in the BRCA1/2 genes; genetic assessment is thus recommended …