Inner ear hair cells (HCs) and spiral ganglion neurons (SGNs) are the core components of
the auditory system. However, they are vulnerable to genetic defects, noise exposure …

Spiral ganglion neurons (SGNs) are auditory neurons that relay sound signals from the inner
ear to the brainstem. The ototoxic drug cisplatin can damage SGNs and thus lead to …

Aging is associated with impairment of sensorial functions and with the onset of
neurodegenerative diseases. As pari passu circulating insulin-like growth factor 1 (IGF-1) …

The mechanoelectrical transduction (MET) channel in auditory hair cells converts sound into
electrical signals, enabling hearing. Transmembrane-like channel 1 and 2 (TMC1 and …

Dync1li1, a subunit of cytoplasmic dynein 1, is reported to play important roles in
intracellular retrograde transport in many tissues. However, the roles of Dync1li1 in the …

Autophagy, a highly conserved cellular mechanism, plays an essential role in the
development and pathology of many central and peripheral nervous system diseases. The …

Background Age-related hearing loss (ARHL), also known as presbycusis, is the most
common sensory impairment seen in elderly people. However, the cochlear aging process …

Prosaposin is a glycoprotein that is widely conserved in vertebrates. It serves as a precursor
for saposins A, B, C, and D, which are necessary activators of lysosomal sphingolipid …

Cochlear ribbon synapses formed between inner hair cells (IHCs) and spiral ganglion
neurons (SGNs) are immature at birth and they require dramatic morphological and …

The development of the inner ear complex cytoarchitecture and functional geometry requires
the exquisite coordination of a variety of cellular processes in a temporal manner. At early …