The bioactive sphingolipid metabolite sphingosine-1-phosphate (S1P) is now recognized as
a critical regulator of many physiological and pathophysiological processes, including …

The bioactive lipid sphingosine-1-phosphate (S1P) is involved in multiple cellular signalling
systems and has a pivotal role in the control of immune cell trafficking. As such, S1P has …

Sphingolipids are critical regulators of tumor microenvironments and play an important role
in estrogen-dependent cancers. Estrogen and estrogen metabolites were found to be …

Sphingolipids are an extensive class of lipids with different functions in the cell, ranging from
proliferation to cell death. Sphingolipids are modified in multiple cancers and are …

One of the classic hallmarks of cancer is the imbalance between elevated cell proliferation
and reduced cell death. Ceramide, a bioactive sphingolipid that can regulate this balance …

The role of sphingolipids as bioactive signaling molecules that can regulate cell fate
decisions puts them at center stage for cancer treatment and prevention. While ceramide …

Sphingolipid metabolism is being increasingly recognized as a key pathway in regulating
cancer cell survival and proliferation. However, very little is known about its role in multiple …

Sphingosine kinase (SphK) is an oncogenic lipid kinase that regulates the sphingolipid
metabolic pathway that has been shown to play a role in numerous hyperproliferative …

Sphingolipids, sphingolipid metabolizing enzymes, and their receptors network are being
recognized as part of the signaling mechanisms, which govern breast cancer cell growth …

There is considerable evidence that sphingosine kinases play a key role in cancer
progression, which might involve positive selection of cancer cells that have been provided …