Cancer is one of the leading causes of death worldwide. Several treatments are available for
cancer treatment, but many treatment methods are ineffective against multidrug-resistant …

Besides their function in limiting blood loss and promoting wound healing, experimental
evidence has highlighted platelets as active players in all steps of tumorigenesis including …

The analysis of extracellular vesicles (EV) in blood samples is under intense investigation
and holds the potential to deliver clinically meaningful biomarkers for health and disease …

Hemostasis encompasses the tightly regulated processes of blood clotting, platelet
activation, and vascular repair. After wounding, the hemostatic system engages a plethora of …

Extensive experimental evidence shows that platelets support tumour metastasis. The
activation of platelets and the coagulation system have a crucial role in the progression of …

P-glycoprotein (P-gp) is a key player in the multidrug-resistant phenotype in cancer. The
protein confers resistance by mediating the ATP-dependent efflux of an astonishing array of …

The coagulation system has gained much interest again as new anticoagulatory substances
have been introduced into clinical practice. Especially patients with renal failure are likely …

When platelet numbers are low or when their function is disabled, the risk of bleeding is
high, which on the one hand indicates that in normal life vascular damage is a rather …

Microparticles (MPs) derived from platelets, monocytes, endothelial cells, red blood cells,
and granulocytes may be detected in low concentrations in normal plasma and at increased …

The syncytiotrophoblast (STB) of human placenta constitutively produces and secretes
extracellular vesicles of different size, morphology and function that enter the maternal …