Application of genetics and biotechnology for improving medicinal plants

M Niazian - Planta, 2019 - Springer
Main conclusion Plant tissue culture has been used for conservation, micropropagation, and
in planta overproduction of some pharma molecules of medicinal plants. New biotechnology …

Genetic manipulation and bioreactor culture of plants as a tool for industry and its applications

T Kowalczyk, A Merecz-Sadowska, L Picot… - Molecules, 2022 - mdpi.com
In recent years, there has been a considerable increase in interest in the use of transgenic
plants as sources of valuable secondary metabolites or recombinant proteins. This has been …

Challenges to antimicrobial stewardship in the countries of the Arab League: concerns of worsening resistance during the COVID-19 pandemic and proposed …

NA Rizk, R Moghnieh, N Haddad, MC Rebeiz… - Antibiotics, 2021 - mdpi.com
The COVID-19 pandemic is expected to worsen the global problem of antimicrobial
resistance (AMR). There is a heightened interest in understanding this effect and to develop …

Transgenesis as a tool for the efficient production of selected secondary metabolites from plant in vitro cultures

T Kowalczyk, J Wieczfinska, E Skała, T Śliwiński… - Plants, 2020 - mdpi.com
The plant kingdom abounds in countless species with potential medical uses. Many of them
contain valuable secondary metabolites belonging to different classes and demonstrating …

In Vitro Evaluation and In Silico Calculations of the Antioxidant and Anti-Inflammatory Properties of Secondary Metabolites from Leonurus sibiricus L. Root Extracts

A Merecz-Sadowska, P Sitarek, T Kowalczyk… - Molecules, 2023 - mdpi.com
Leonurus sibiricus L. has great ethnobotanical and ethnomedicinal significance. This study
aimed to assess the antioxidant and anti-inflammatory properties of Leonurus sibiricus L …

Plant in vitro systems as a sustainable source of active ingredients for cosmeceutical application

AS Marchev, MI Georgiev - Molecules, 2020 - mdpi.com
Cosmeceuticals are hybrids between cosmetics and pharmaceuticals which are being
designed for a dual purpose:(1) To provide desired esthetical effects and (2) simultaneously …

Enhanced Accumulation of Betulinic Acid in Transgenic Hairy Roots of Senna obtusifolia Growing in the Sprinkle Bioreactor and Evaluation of Their Biological …

T Kowalczyk, P Sitarek, M Toma, P Rijo… - Chemistry & …, 2021 - Wiley Online Library
Betulinic acid, which is found in transgenic roots of Senna obtusifolia (L.) HS Irwin &
Barneby, is a pentacyclic triterpene with distinctive pharmacological activities. In this study …

Improving large-scale biomass and total alkaloid production of Dendrobium nobile Lindl. using a temporary immersion bioreactor system and MeJA elicitation

B Zhang, Z Niu, C Li, Z Hou, Q Xue, W Liu, X Ding - Plant Methods, 2022 - Springer
Abstract Background Dendrobium nobile Lindl. is an important pharmacopeial plant with
medicinal and ornamental value. This study sought to provide a technical means for the …

Caffeoylquinic Acids with Potential Biological Activity from Plant In vitro Cultures as Alternative Sources of Valuable Natural Products

E Skała, J Makowczyńska, J Wieczfinska… - Current …, 2020 - benthamdirect.com
Background: For a long time, the researchers have been looking for new efficient methods to
enhance production and obtain valuable plant secondary metabolites, which would …

Preliminary phytochemical analysis and evaluation of the biological activity of Leonotis nepetifolia (L.) r. br transformed roots extracts obtained through rhizobium …

T Kowalczyk, A Merecz-Sadowska, P Rijo, VMS Isca… - Cells, 2021 - mdpi.com
According to the present knowledge, this is the first report on establishing transformed root
cultures of Leonotis nepetifolia after Rhizobium rhizogenes-mediated transformation. The …