The unnatural amino acids (UAAs) are members of a class of molecules with relevant
impacts in the life sciences. Due to the role of these molecules in the modulation of the …

Active pharmaceutical ingredients (APIs) can be divided into two types, namely chemical
and biological entities. Traditionally, the former has been associated with the so‐called …

During the last years, transition-metal-catalyzed carbon-hydrogen bond functionalization
has witnessed an explosive growth.[1] The use of CH bond as a functional group is …

A copper-catalyzed asymmetric synthesis of unnatural β-germyl α-amino acids is developed.
This process undergoes an intermolecular enantioselective hydrogermylation of …

A direct copper-catalyzed highly chemoselective α-amination is described. Acylpyrazole
proved to be a highly efficient enolate precursor of a carboxylic acid oxidation state …

A site-selective alkylation of dehydroalanine to access protected unnatural amino acids is
described. The protocol is characterized by the wide nature of alkyl radicals employed, mild …

We report a class of quaternary ammonium Cinchona-functionalized crown ether-strapped
calix [4] arene phase-transfer catalysts for the efficient enantioselective α-alkylation of …

The enantioselective α‐functionalisation of glycine Schiff base aryl esters through
isothiourea catalysis is successfully demonstrated for 1, 6‐additions to para‐quinone …

An organocatalytic system is presented for the Michael addition of monoactivated glycine
ketimine ylides with a bifunctional catalyst. The ketimine bears an ortho hydroxy group …

A direct asymmetric reductive amination of α-keto acids catalyzed by Cp* Ir complexes
bearing a chiral N-(2-picolyl) sulfonamidato ligand is described. The combined use of …