DNA replication is a complicated process that is largely regulated during stages of initiation.
The Siman Virus 40 in vitro replication system has served as an excellent model for studies …

The initial steps in the formation of the initiation complex at oriC of Bacillus subtilis were
analyzed with special emphasis on the exchangeability of B. subtilis DnaA protein by DnaA …

Publisher Summary Many viral infections have a profound impact on host fitness and
survival and thus affect host evolution. DNA viruses have a tendency to establish lifelong …

The infection process by simian virus 40 (SV40) and entry of its genome into nondividing
cells are only partly understood. Infection begins by binding to GM1 receptors at the cell …

Cell cycle-dependent phosphorylation of simian virus 40 (SV40) large tumor antigen (T-ag)
on threonine 124 is essential for the initiation of viral DNA replication. A T-ag molecule …

ABSTRACT BK virus (BKV) causes persistent and asymptomatic infections in most humans
and is the etiologic agent of polyomavirus-associated nephropathy (PVAN) and other …

Mouse polyomavirus (MPyV) is considered a potential tool for the application of gene
therapy; however, the current knowledge of the encapsulation of DNA into virions is vague …

Replication of the genomes of the polyomaviruses requires two virus-specified elements, the
cis-acting origin of DNA replication, with its auxiliary DNA elements, and the trans-acting …

The coding region of polyomavirus large T antigen was engineered into the genome of the
methylotrophic yeast Pichia pastoris by use of the vector pHIL-D2. Expression of large T …

Polyomavirus large T antigen binds to multiple 5′-G (A/G) GGC-3′ pentanucleotide
sequences in sites 1/2, A, B, and C within and adjacent to the origin of viral DNA replication …