The field of vascular biology has gained enormous insight from the use of Cre and inducible
Cre mouse models to temporally and spatially manipulate gene expression within the …

The heart is a complex organ consisting of various cell types, each of which plays an
important role in both physiological and pathophysiological conditions. The cells …

The systemic biodistribution of endogenous extracellular vesicles is central to the
maintenance of tissue homeostasis. Here, we show that angiogenesis and heart function in …

Passage of systemically delivered pharmacological agents into the brain is largely blocked
by the blood-brain-barrier (BBB), an organotypic specialization of brain endothelial cells …

Endothelial sprouting and proliferation are tightly coordinated processes mediating the
formation of new blood vessels during physiological and pathological angiogenesis …

Characterizing the stem cells responsible for lung repair and regeneration is important for
the treatment of pulmonary diseases. Recently, a unique cell population located at the …

Monitoring of cell-cell communication in multicellular organisms is fundamental to
understanding diverse biological processes such as embryogenesis and tumorigenesis. To …

The lung microvasculature is essential for gas exchange and commonly considered
homogeneous. We show that VEGFA from the epithelium is required for a distinct …

The Cre–loxP recombination system is the most widely used technology for in vivo tracing of
stem or progenitor cell lineages. The precision of this genetic system largely depends on the …

Background: Whether the adult mammalian heart harbors cardiac stem cells for
regeneration of cardiomyocytes is an important yet contentious topic in the field of …