Iron-sulfur (Fe-S) clusters are fundamental to numerous biological processes in most
organisms, but these protein cofactors can be prone to damage by various oxidants (eg, O2 …

IscR is an iron‐sulphur (Fe‐S) cluster‐containing transcription factor that represses
transcription of the operon containing its own gene and the iscSUA‐hscBA‐fdx genes …

Iron–sulfur clusters are essential cofactors in a myriad of metabolic pathways. Therefore,
their biogenesis is tightly regulated across a variety of organisms and environmental …

Summary In Escherichia coli, Fe‐S clusters are assembled by gene products encoded from
the isc and suf operons. Both the iscRSUA and sufABCDSE operons are induced highly by …

A promoter (sufAp), inducible by various oxidants, directs transcription of the sufABCDSE
operon encoding an alternative Fe‐S cluster assembly system in Escherichia coli …

The suf operon encoding a Fe-S assembly system is induced by peroxides through
activators OxyR and IscR in Escherichia coli. For apo-IscR to bind, oxidation-mediated …

Fe-S cluster biogenesis is essential for the viability of most organisms. In Escherichia coli,
this process requires either the housekeeping Isc or the stress-induced Suf pathway. The …

Transcription is fundamentally noisy, leading to significant heterogeneity across bacterial
populations. Noise is often attributed to burstiness, but the underlying mechanisms and their …

Despite the mammalian host actively sequestering iron to limit pathogenicity, heme (or
hemin when oxidized) and hemoproteins serve as important sources of iron for many …

The role of IscR in regulating the transcription of genes involved in Fesingle bondS cluster
homeostasis has been well established for the model organism Escherichia coli K12. In this …