Sodium-glucose co-transporter 2 (SGLT2) inhibitors block glucose reabsorption in the renal
proximal tubule, an insulin-independent mechanism that plays a critical role in glycemic …

Mitchell Arterial Stiffness and Hypertension 211 in PP that is associated with high incidence
of predominantly systolic hypertension in older people. One of the foregoing studies of …

Townsend et al Vascular Research on Arterial Stiffness 699 pressure, blood flow, and
arterial diameter change with each heartbeat. In addition to the passive mechanical …

Prevention of cardiovascular disease (CVD) remains one of the largest public health
challenges of our time. Identifying individuals at increased cardiovascular risk at an …

Background—Inorganic nitrate (NO3−), abundant in certain vegetables, is converted to
nitrite by bacteria in the oral cavity. Nitrite can be converted to nitric oxide in the setting of …

The optimal performance of the cardiovascular system, as well as the break-down of this
performance with disease, both involve complex biomechanical interactions between the …

Objectives Recently, a novel method to estimate aortic pulse wave velocity (aPWV)
noninvasively from an oscillometric single brachial cuff waveform reading has been …

Background: Whether the combination of different blood pressure and arterial stiffness (AS)
status is independently associated with diabetes has not been fully investigated so far. This …

From a clinical perspective, type 2 diabetes mellitus might also be regarded as a vascular
disease, characterized by increased arterial stiffness. Empagliflozin is a selective sodium …

Background Empagliflozin has been shown to reduce cardiovascular mortality, but the
underlying pathogenetic mechanisms are poorly understood. It was previously …