The alfa and beta of tumours: a review of parameters of the linear-quadratic model, derived from clinical radiotherapy studies
Background Prediction of radiobiological response is a major challenge in radiotherapy. Of
several radiobiological models, the linear-quadratic (LQ) model has been best validated by …
several radiobiological models, the linear-quadratic (LQ) model has been best validated by …
Biological principles of stereotactic body radiation therapy (SBRT) and stereotactic radiation surgery (SRS): indirect cell death
CW Song, E Glatstein, LB Marks, B Emami… - International Journal of …, 2021 - Elsevier
Purpose To review the radiobiological mechanisms of stereotactic body radiation therapy
stereotactic body radiation therapy (SBRT) and stereotactic radiation surgery (SRS) …
stereotactic body radiation therapy (SBRT) and stereotactic radiation surgery (SRS) …
The radiobiology of hypofractionation
AE Nahum - Clinical oncology, 2015 - Elsevier
If the α/β ratio is high (eg 10 Gy) for tumour clonogen killing, but low (eg 3 Gy) for late normal
tissue complications, then delivering external beam radiotherapy in a large number (20–30) …
tissue complications, then delivering external beam radiotherapy in a large number (20–30) …
The international commission on radiation units and measurements
HG Menzel - Journal of the ICRU, 2012 - journals.sagepub.com
The International Commission on Radiation Units and Measurements - Hans-Georg Menzel,
2012 Skip to main content Scheduled maintenance on Monday, November 20th, with …
2012 Skip to main content Scheduled maintenance on Monday, November 20th, with …
The linear-quadratic approach in clinical practice
SM Bentzen, MC Joiner - Basic clinical radiobiology, 2018 - taylorfrancis.com
As soon as relatively accurate dosimetry became available around 1910, it became clear
that the biological effect of a given physical dose of ionizing radiation depends on how this …
that the biological effect of a given physical dose of ionizing radiation depends on how this …
The limitations of model-based experimental design and parameter estimation in sloppy systems
We explore the relationship among experimental design, parameter estimation, and
systematic error in sloppy models. We show that the approximate nature of mathematical …
systematic error in sloppy models. We show that the approximate nature of mathematical …
[HTML][HTML] Radiotherapy in preclinical models of brain metastases: a review and recommendations for future studies
W Shi, G Tanzhu, L Chen, J Ning, H Wang… - … Journal of Biological …, 2024 - ncbi.nlm.nih.gov
Brain metastases (BMs) frequently occur in primary tumors such as lung cancer, breast
cancer, and melanoma, and are associated with notably short natural survival. In addition to …
cancer, and melanoma, and are associated with notably short natural survival. In addition to …
Ablative hypofractionated radiation therapy enhances non-small cell lung cancer cell killing via preferential stimulation of necroptosis in vitro and in vivo
HH Wang, ZQ Wu, D Qian, NG Zaorsky, MH Qiu… - International Journal of …, 2018 - Elsevier
Purpose To investigate how necroptosis (ie, programmed necrosis) is involved in killing of
non-small cell lung cancer (NSCLC) after ablative hypofractionated radiation therapy …
non-small cell lung cancer (NSCLC) after ablative hypofractionated radiation therapy …
[图书][B] A guide to outcome modeling in radiotherapy and oncology: listening to the data
I El Naqa - 2018 - books.google.com
This book explores outcome modeling in cancer from a data-centric perspective to enable a
better understanding of complex treatment response, to guide the design of advanced …
better understanding of complex treatment response, to guide the design of advanced …
A generalized target theory and its applications
L Zhao, D Mi, B Hu, Y Sun - Scientific reports, 2015 - nature.com
Different radiobiological models have been proposed to estimate the cell-killing effects,
which are very important in radiotherapy and radiation risk assessment. However, most …
which are very important in radiotherapy and radiation risk assessment. However, most …