Depression is highly common throughout the life course and dementia is common in late life.
Depression has been linked with dementia, and growing evidence implies that the timing of …

Our understanding of the pathogenesis of diseases has advanced enormously in recent
decades. As a consequence, drug discovery has gradually shifted from an entirely …

With 27 million cases worldwide documented in 2006, Alzheimer's disease (AD) constitutes
an overwhelming health, social, economic, and political problem to nations. Unless a new …

Alzheimerβs disease (AD) is a multifactorial neurodegenerative disorder with several target
proteins contributing to its aetiology. Pathological, genetic, biochemical, and modeling …

More than 50 million people have various forms of cognitive impairment basically caused by
neurodegenerative diseases, such as Alzheimer's, Parkinson's, and cerebrovascular …

Alzheimer's disease (AD) is a neurodegenerative disease characterized by memory and
cognitive loss, and represents the leading cause of dementia in elderly people. Besides the …

Background: exercise may reduce depressive symptoms both in healthy aged populations
and in old patients diagnosed with MDD, but few specific analysis were conducted on the …

Objective To determine whether less severe depression spectrum diagnoses such as
dysthymia, as well as depression, are associated with risk of developing dementia and …

Protein–protein interactions are a crucial element in cellular function. The wealth of
information currently available on intracellular-signaling pathways has led many to …

The gut microbiome interacts with the brain bidirectionally through the microbiome-gutbrain
axis, which plays a key role in regulating various nervous system pathophysiological …