Ultra-high-performance liquid chromatography high-resolution mass spectrometry (UHPLC–
HRMS) variants currently represent the best tools to tackle the challenges of complexity and …

This review article compares and contrasts sample preparation techniques coupled with
high-performance liquid chromatography (HPLC) and describes applications developed in …

Although, LC–MS is one of the most sensitive and selective analytical techniques, it often
suffers from matrix effects, especially when using ESI for analyzing extracts of complicated …

Solid-phase extraction (SPE) is the most widely used method for the extraction, changing of
solvents, cleanup, concentration, and fractionation of organic compounds from a number of …

Highlights•Chromatography-based mass spectrometry (MS) allows profiling 100 samples
per day.•Thousands of samples per day can be efficiently analyzed by omitting …

Organoids are 3D models of organs, grown in the laboratory from stem cells. An organ
model grown/placed in microfluidic devices is commonly termed an “organ-on-a-chip” …

This review aims at presenting the state of the art concerning monolithic materials for on-line
sample preparation emphasizing solid-phase extraction, matrix exchange, and analyte …

In proteomics, nano-LC is arguably the most common tool for separating peptides/proteins
prior to MS. The main advantage of nano-LC is enhanced sensitivity, as compounds enter …

Glycans on proteins and lipids are known to alter with malignant transformation. The study of
these may contribute to the discovery of biomarkers and treatment targets as well as …

Metabolomics is one of the most rapidly evolving of the omics sciences. For phenotyping
individuals, it offers a promising platform that is needed for breakthroughs in biomedical and …