The ribosome is one of the main antibiotic targets in the bacterial cell. Crystal structures of
naturally produced antibiotics and their semi-synthetic derivatives bound to ribosomal …

Antimicrobial resistance presents us with a potential global crisis as it undermines the
abilities of conventional antibiotics to combat pathogenic microbes. The history of …

Disruption of cell–cell communication or quorum sensing (QS) is considered a stimulating
approach for reducing bacterial pathogenicity and resistance. Although several QS inhibitors …

In prokaryotic systems, the initiation phase of protein synthesis is governed by the presence
of initiation factors that guide the transition of the small ribosomal subunit (30S) from an …

A general procedure for the synthesis of ethyl Z-3-halo-3-nitroacrylates by the reaction of
ethyl 3-nitroacrylate with Cl 2 or Br 2 followed by dehydrohalogenation was proposed. Ethyl …

The use of antibiotics has revolutionized medicine, greatly improving our capacity to save
millions of lives from otherwise deadly bacterial infections. Unfortunately, the health …

The translocation of mRNA and tRNA through the ribosome is catalyzed by elongation factor
G (EF-G), a universally conserved guanosine triphosphate hydrolase (GTPase). The …

Aminoglycoside antibiotics are widely used to treat infectious diseases. Among them,
streptomycin and kanamycin (and derivatives) are of importance to battle multidrug-resistant …

GE81112 is a tetrapeptide antibiotic that binds to the 30S ribosomal subunit and specifically
inhibits P-site decoding of the mRNA initiation codon by the fMet-tRNA anticodon. GE81112 …

The unique antimicrobial mechanism of antimicrobials make them a promising substitute for
antibiotics for fighting drug-resistant bacteria. Both melittin and thanatin have antimicrobial …