Recent years have seen significant advances in our understanding of the development and
function of the adrenal gland together with further insights into the physiologic and …

Pseudohypoaldosteronism (PHA) is a rare syndrome of mineralocorticoid resistance. PHA
type 1 (PHA1) can be divided into two different forms, showing either a systemic or a renal …

Autosomal dominant pseudohypoaldosteronism type 1 (adPHA1) is a rare condition that is
characterized by renal resistance to aldosterone, with salt wasting, hyperkalemia, and …

Aldosterone is crucial for regulating sodium conservation in the kidney, salivary glands,
sweat glands, and colon. This adrenal steroid hormone acts via the mineralocorticoid …

In newborns and infants, dehydration and salt wasting represent a relatively common cause
of admission to hospital and may result in life-threatening complications. Kidneys are …

The cause of primary hypertension is unknown but the normal distribution of blood pressure
in the population, of which hypertension represents the upper tail, suggests a multifactorial …

Type I pseudohypoaldosteronism (PHA-1) is a rare salt wasting syndrome occurring soon
after birth, characterized by apathy and severe dehydration accompanied by hyponatremia …

Renal pseudohypoaldosteronism (PHA1) is a mild form of an aldosterone-resistance
syndrome caused by mutations in the NR3C2 gene that codes for the mineralocorticoid …

Growth hormone (GH) treatment causes salt and water retention, and this effect has been
suggested to be mediated by activation of epithelial sodium channel (ENaC). Multi-system …

Our understanding of Na+ transport defects has exploded in the past several years, and has
provided unique insights into epithelial transport processes, and unusual clinical syndromes …