A Comprehensive Review of HLA and Severe Cutaneous Adverse Drug Reactions: Implication for Clinical Pharmacogenomics and Precision Medicine
C Kloypan, N Koomdee, P Satapornpong, T Tempark… - Pharmaceuticals, 2021 - mdpi.com
Human leukocyte antigen (HLA) encoded by the HLA gene is an important modulator for
immune responses and drug hypersensitivity reactions as well. Genetic polymorphisms of …
immune responses and drug hypersensitivity reactions as well. Genetic polymorphisms of …
[HTML][HTML] Drug-induced severe cutaneous adverse reactions: insights into clinical presentation, immunopathogenesis, diagnostic methods, treatment, and …
T Tempark, S John, P Rerknimitr… - Frontiers in …, 2022 - frontiersin.org
SCARs are rare and life-threatening hypersensitivity reactions. In general, the increased
duration of hospital stays and the associated cost burden are common issues, and in the …
duration of hospital stays and the associated cost burden are common issues, and in the …
[HTML][HTML] An updated review of genetic associations with severe adverse drug reactions: translation and implementation of pharmacogenomic testing in clinical practice
CW Wang, IAC Preclaro, WH Lin… - Frontiers in …, 2022 - frontiersin.org
Adverse drug reactions (ADR) remain the major problems in healthcare. Most severe ADR
are unpredictable, dose-independent and termed as type B idiosyncratic reactions. Recent …
are unpredictable, dose-independent and termed as type B idiosyncratic reactions. Recent …
Pharmacogenetics and precision medicine approaches for the improvement of COVID-19 therapies
M Biswas, N Sawajan, T Rungrotmongkol… - Frontiers in …, 2022 - frontiersin.org
Many drugs are being administered to tackle coronavirus disease 2019 (COVID-19)
pandemic situations without establishing clinical effectiveness or tailoring safety. A …
pandemic situations without establishing clinical effectiveness or tailoring safety. A …
Current understanding of genetic associations with delayed hypersensitivity reactions induced by antibiotics and anti-osteoporotic drugs
Drug-induced delayed hypersensitivity reactions (DHRs) is still a clinical and healthcare
burden in every country. Increasing reports of DHRs have caught our attention to explore the …
burden in every country. Increasing reports of DHRs have caught our attention to explore the …
Association between HLA alleles and beta-lactam antibiotics-related severe cutaneous adverse reactions
P Wattanachai, W Amornpinyo, P Konyoung… - Frontiers in …, 2023 - frontiersin.org
Introduction: Beta-lactam antibiotics are one of the most common causes of antibiotics-
related severe cutaneous adverse reactions (SCARs) including Stevens–Johnson syndrome …
related severe cutaneous adverse reactions (SCARs) including Stevens–Johnson syndrome …
[HTML][HTML] Current pharmacogenetic perspective on Stevens-Johnson syndrome and toxic epidermal necrolysis
L Cheng - Frontiers in Pharmacology, 2021 - frontiersin.org
Adverse drug reactions are a public health issue that draws widespread attention, especially
for Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) which have high …
for Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) which have high …
Genotyping HLA alleles to predict the development of Severe cutaneous adverse drug reactions (SCARs): state-of-the-art
T Jantararoungtong, T Tempark… - Expert Opinion on …, 2021 - Taylor & Francis
Introduction: Pharmacogenomics has great potential in reducing drug-induced severe
cutaneous adverse drug reactions (SCARs). Pharmacogenomic studies have revealed an …
cutaneous adverse drug reactions (SCARs). Pharmacogenomic studies have revealed an …
[HTML][HTML] Genomic risk factors driving immune-mediated delayed drug hypersensitivity reactions
Y Li, P Deshpande, RJ Hertzman, AM Palubinsky… - Frontiers in …, 2021 - frontiersin.org
Adverse drug reactions (ADRs) remain associated with significant mortality. Delayed
hypersensitivity reactions (DHRs) that occur greater than 6 h following drug administration …
hypersensitivity reactions (DHRs) that occur greater than 6 h following drug administration …
HLA Allele–Restricted Immune-Mediated Adverse Drug Reactions: Framework for Genetic Prediction
K Jaruthamsophon, PJ Thomson… - Annual Review of …, 2022 - annualreviews.org
Human leukocyte antigen (HLA) is a hallmark genetic marker for the prediction of certain
immune-mediated adverse drug reactions (ADRs). Numerous basic and clinical research …
immune-mediated adverse drug reactions (ADRs). Numerous basic and clinical research …