C. NADP synthesis D. Catabolism of NAD and NADP E. Relationships between NAD and
NADP F. NAD transport across mitochondrial membranes G. NAD transport across the …

There is substantial evidence that oxidative stress participates in the pathophysiology of
cardiovascular disease. Biochemical, molecular and pharmacological studies further …

Intracellular concentrations of redox-active molecules can significantly increase in the heart
as a result of activation of specific signal transduction pathways or the development of …

Metabolites, including those generated during ethanol metabolism, can impact disease
states by binding to transcription factors and/or modifying chromatin structure, thereby …

Mitochondria are central to energy metabolism as the source of much of the cell's ATP, as
well as being a hub for cellular Ca 2+ signaling. Mitochondrial Ca 2+ is a positive effector of …

The appropriate secretion of insulin from pancreatic β-cells is critically important to the
maintenance of energy homeostasis. The β-cells must sense and respond suitably to …

Introduction 3. NAD+ and NADH metabolism in cells 3.1. General information about NAD+
and NADH 3.2. NAD+ and NADH synthesis 3.3. NAD+ and NADH catabolism 4. NAD+ and …

The release of Ca2+ ions from intracellular stores is a key step in a wide variety of cellular
functions. In striated muscle, the release of Ca2+ from the sarcoplasmic reticulum (SR) leads …

NADH and Ca2+ have important regulatory functions in cardiomyocytes related to excitation-
contraction coupling and ATP production. To elucidate elements of these functions, we …

In the heart ischaemic conditions induce metabolic changes known to have profound effects
on Ca2+ signalling during excitation–contraction coupling. Ischaemia also affects the redox …