In the last decade, carbohydrate microarrays have been core technologies for analyzing
carbohydrate-mediated recognition events in a high-throughput fashion. A number of …

Aberrant expression of glycosphingolipids is a hallmark of cancer cells and is associated
with their malignant properties. Disialylated gangliosides GD2 and GD3 are considered as …

Alterations in metabolic pathways are a hallmark of cancer. A deeper understanding of the
contribution of different metabolites to carcinogenesis is thus vitally important to elucidate …

Glycosphingolipids (GSLs) are ubiquitous components of eukaryotic plasma membranes
that consist of a ceramide backbone linked to a glycan moiety. Both the ceramide and the …

Pancreatic cancer (PC; pancreatic ductal adenocarcinoma) is characterized by significant
morbidity and mortality worldwide. Although carbohydrate antigen (CA) 19-9 has been …

Conventional targeted therapies for the treatment of cancer have limitations, including the
development of acquired resistance. However, novel alternatives have emerged in the form …

Altered networks of gene regulation underlie many pathologies, including cancer. There are
several proteins in cancer cells that are turned either on or off, which dramatically alters the …

Glycans are important in most biological processes, yet the exact insights into their functions
remain enigmatic due to the lack of suitable tools for their analysis. Glycoproteins have …

Serum anti-glycan antibodies play important roles in many immune processes and are of
particular interest as biomarkers for many diseases. Changes in anti-glycan antibodies can …

Disialoganglioside (GD2) is a subtype of glycolipids that is highly expressed in tumors of
neuroectodermal origins, such as neuroblastoma and osteosarcoma. Its limited expression …