Photocatalytic late-stage C–H functionalization
The emergence of modern photocatalysis, characterized by mildness and selectivity, has
significantly spurred innovative late-stage C–H functionalization approaches that make use …
significantly spurred innovative late-stage C–H functionalization approaches that make use …
A brief introduction to chemical reaction optimization
From the start of a synthetic chemist's training, experiments are conducted based on recipes
from textbooks and manuscripts that achieve clean reaction outcomes, allowing the scientist …
from textbooks and manuscripts that achieve clean reaction outcomes, allowing the scientist …
Technological innovations in photochemistry for organic synthesis: flow chemistry, high-throughput experimentation, scale-up, and photoelectrochemistry
L Buglioni, F Raymenants, A Slattery… - Chemical …, 2021 - ACS Publications
Photoinduced chemical transformations have received in recent years a tremendous amount
of attention, providing a plethora of opportunities to synthetic organic chemists. However …
of attention, providing a plethora of opportunities to synthetic organic chemists. However …
Photocatalysis in the life science industry
L Candish, KD Collins, GC Cook, JJ Douglas… - Chemical …, 2021 - ACS Publications
In the pursuit of new pharmaceuticals and agrochemicals, chemists in the life science
industry require access to mild and robust synthetic methodologies to systematically modify …
industry require access to mild and robust synthetic methodologies to systematically modify …
New strategies for the transition-metal catalyzed synthesis of aliphatic amines
A Trowbridge, SM Walton, MJ Gaunt - Chemical reviews, 2020 - ACS Publications
Transition-metal catalyzed reactions that are able to construct complex aliphatic amines from
simple, readily available feedstocks have become a cornerstone of modern synthetic …
simple, readily available feedstocks have become a cornerstone of modern synthetic …
Recent advances in minisci‐type reactions
RSJ Proctor, RJ Phipps - Angewandte Chemie International …, 2019 - Wiley Online Library
Reactions that involve the addition of carbon‐centered radicals to basic heteroarenes,
followed by formal hydrogen atom loss, have become widely known as Minisci‐type …
followed by formal hydrogen atom loss, have become widely known as Minisci‐type …
Accelerated chemical reaction optimization using multi-task learning
Functionalization of C–H bonds is a key challenge in medicinal chemistry, particularly for
fragment-based drug discovery (FBDD) where such transformations require execution in the …
fragment-based drug discovery (FBDD) where such transformations require execution in the …
Emerging concepts in photocatalytic organic synthesis
S Reischauer, B Pieber - Iscience, 2021 - cell.com
Visible light photocatalysis has become a powerful tool in organic synthesis that uses
photons as traceless, sustainable reagents. Most of the activities in the field focus on the …
photons as traceless, sustainable reagents. Most of the activities in the field focus on the …
Hydrogen atom transfer-driven enantioselective minisci reaction of amides
RSJ Proctor, P Chuentragool, AC Colgan… - Journal of the …, 2021 - ACS Publications
Minisci-type reactions constitute one of the most powerful methods for building up
complexity around basic heteroarenes. The most desirable variants involve formal oxidative …
complexity around basic heteroarenes. The most desirable variants involve formal oxidative …
Rapid optimization of photoredox reactions for continuous-flow systems using microscale batch technology
M González-Esguevillas, DF Fernández… - ACS Central …, 2021 - ACS Publications
Photoredox catalysis has emerged as a powerful and versatile platform for the synthesis of
complex molecules. While photocatalysis is already broadly used in small-scale batch …
complex molecules. While photocatalysis is already broadly used in small-scale batch …