The microenvironment (local environment), including viscosity, temperature, polarity,
hypoxia, and acidic-basic status (pH), plays indispensable roles in cellular processes …

The microenvironment is indispensable for functionality of various biomacromolecules,
subcellular compartments, living cells, and organisms. In particular, physical properties …

Polarity, as a complex parameter, plays pivotal roles in chemistry and biology. Deviant
polarity change in different subcellular compartments is closely connected with diseases …

Proper three-dimensional structures are essential for maintaining the functionality of proteins
and for avoiding pathological consequences of improper folding. Misfolding and …

Physico-chemical mobility of cells in three dimensions is dependent on the development of
filipodia, which is the fundamental instinct for survival and other cellular functions in live …

In Alzheimer's disease (AD), the initial stages of the aggregation process of the β-amyloid
peptide (Aβ) present a particular interest to understand the origin of the development of this …

Unraveling cellular physiological processes via luminescent probes that target specific
cellular microenvironments is quite challenging due to the uneven distribution of probes …

Recently, it was proposed that the thiophene ring is capable of promoting mitochondrial
accumulation when linked to fluorescent markers. As a noncharged group, thiophene …

In this work the preferential accumulation of long-lived acridone derivatives in mitochondria
were evaluated, based on a new concept of non-protonable and non-charged group …

The precise knowledge of intracellular polarity, a physiological parameter that involves
complex and intertwined intracellular mechanisms, may be relevant in the study of important …