Electrostatic interactions in protein structure, folding, binding, and condensation
Charged and polar groups, through forming ion pairs, hydrogen bonds, and other less
specific electrostatic interactions, impart important properties to proteins. Modulation of the …
specific electrostatic interactions, impart important properties to proteins. Modulation of the …
In-cell structural biology by NMR: the benefits of the atomic scale
FX Theillet - Chemical reviews, 2022 - ACS Publications
In-cell structural biology aims at extracting structural information about proteins or nucleic
acids in their native, cellular environment. This emerging field holds great promise and is …
acids in their native, cellular environment. This emerging field holds great promise and is …
[HTML][HTML] Transcription factors activate genes through the phase-separation capacity of their activation domains
Gene expression is controlled by transcription factors (TFs) that consist of DNA-binding
domains (DBDs) and activation domains (ADs). The DBDs have been well characterized …
domains (DBDs) and activation domains (ADs). The DBDs have been well characterized …
Phase separation drives RNA virus-induced activation of the NLRP6 inflammasome
NLRP6 is important in host defense by inducing functional outcomes including
inflammasome activation and interferon production. Here, we show that NLRP6 undergoes …
inflammasome activation and interferon production. Here, we show that NLRP6 undergoes …
[HTML][HTML] De novo engineering of intracellular condensates using artificial disordered proteins
Phase separation of intrinsically disordered proteins (IDPs) is a remarkable feature of living
cells to dynamically control intracellular partitioning. Despite the numerous new IDPs that …
cells to dynamically control intracellular partitioning. Despite the numerous new IDPs that …
Intrinsically disordered proteins: critical components of the wetware
P Kulkarni, S Bhattacharya, S Achuthan… - Chemical …, 2022 - ACS Publications
Despite the wealth of knowledge gained about intrinsically disordered proteins (IDPs) since
their discovery, there are several aspects that remain unexplored and, hence, poorly …
their discovery, there are several aspects that remain unexplored and, hence, poorly …
Physics-based computational and theoretical approaches to intrinsically disordered proteins
Highlights•Liquid-liquid phase separation underlies the formation of membraneless
organelles within cells.•Theory and molecular simulations help to relate interactions at the …
organelles within cells.•Theory and molecular simulations help to relate interactions at the …
Microglial-derived C1q integrates into neuronal ribonucleoprotein complexes and impacts protein homeostasis in the aging brain
Neuroimmune interactions mediate intercellular communication and underlie critical brain
functions. Microglia, CNS-resident macrophages, modulate the brain through direct physical …
functions. Microglia, CNS-resident macrophages, modulate the brain through direct physical …
DisProt: intrinsic protein disorder annotation in 2020
Abstract The Database of Protein Disorder (DisProt, URL: https://disprot. org) provides
manually curated annotations of intrinsically disordered proteins from the literature. Here we …
manually curated annotations of intrinsically disordered proteins from the literature. Here we …
Interaction dynamics of intrinsically disordered proteins from single-molecule spectroscopy
A Chowdhury, D Nettels… - Annual review of …, 2023 - annualreviews.org
Many proteins contain large structurally disordered regions or are entirely disordered under
physiological conditions. The functions of these intrinsically disordered proteins (IDPs) often …
physiological conditions. The functions of these intrinsically disordered proteins (IDPs) often …