The far-reaching scope of neuroinflammation after traumatic brain injury

DW Simon, MJ McGeachy, H Bayır, RSB Clark… - Nature Reviews …, 2017 - nature.com
The'silent epidemic'of traumatic brain injury (TBI) has been placed in the spotlight as a result
of clinical investigations and popular press coverage of athletes and veterans with single or …

Severe traumatic brain injury: targeted management in the intensive care unit

N Stocchetti, M Carbonara, G Citerio, A Ercole… - The Lancet …, 2017 - thelancet.com
Severe traumatic brain injury (TBI) is currently managed in the intensive care unit with a
combined medical–surgical approach. Treatment aims to prevent additional brain damage …

Necroptosis: a novel pathway in neuroinflammation

Z Yu, N Jiang, W Su, Y Zhuo - Frontiers in pharmacology, 2021 - frontiersin.org
Neuroinflammation is a complex inflammatory process in the nervous system that is
expected to play a significant role in neurological diseases. Necroptosis is a kind of necrosis …

Interoceptive regulation of skeletal tissue homeostasis and repair

Y Xiao, C Han, Y Wang, X Zhang, R Bao, Y Li, H Chen… - Bone Research, 2023 - nature.com
Recent studies have determined that the nervous system can sense and respond to signals
from skeletal tissue, a process known as skeletal interoception, which is crucial for …

[HTML][HTML] Blood-based biomarkers of inflammation in mild traumatic brain injury: A systematic review

K Visser, M Koggel, J Blaauw, HJ van der Horn… - Neuroscience & …, 2022 - Elsevier
Abstract VISSER, K., M. Koggel, J. Blaauw, HJvd Horn, B. Jacobs, and Jvd Naalt. Blood
based biomarkers of inflammation in mild traumatic brain injury: A systematic review …

MiR-124 enriched exosomes promoted the M2 polarization of microglia and enhanced hippocampus neurogenesis after traumatic brain injury by inhibiting TLR4 …

Y Yang, Y Ye, C Kong, X Su, X Zhang, W Bai… - Neurochemical …, 2019 - Springer
Abstract MicroRNA-124 (miR-124) is a brain specific miRNA that is highly expressed in
microglia. The upregulation of miR-124 contributes to M2 polarization of microglia, which is …

An overview of management of intracranial hypertension in the intensive care unit

T Schizodimos, V Soulountsi, C Iasonidou… - Journal of …, 2020 - Springer
Intracranial hypertension (IH) is a clinical condition commonly encountered in the intensive
care unit, which requires immediate treatment. The maintenance of normal intracranial …

Beyond the brain: peripheral interactions after traumatic brain injury

SJ McDonald, JM Sharkey, M Sun… - Journal of …, 2020 - liebertpub.com
Traumatic brain injury (TBI) is a leading cause of death and disability, and there are currently
no pharmacological treatments known to improve patient outcomes. Unquestionably …

GFAP and S100B: what you always wanted to know and never dared to ask

D Janigro, S Mondello, JP Posti, J Unden - Frontiers in neurology, 2022 - frontiersin.org
Traumatic brain injury (TBI) is a major global health issue, with outcomes spanning from
intracranial bleeding, debilitating sequelae, and invalidity with consequences for individuals …

The potential for animal models to provide insight into mild traumatic brain injury: translational challenges and strategies

SR Shultz, SJ McDonald, CV Haar, A Meconi… - Neuroscience & …, 2017 - Elsevier
Mild traumatic brain injury (mTBI) is a common health problem. There is tremendous
variability and heterogeneity in human mTBI, including mechanisms of injury, biomechanical …