During angiogenesis, new vessels emerge from existing endothelial lined vessels to
promote the degradation of the vascular basement membrane and remodel the extracellular …

Colorectal cancer (CRC) is a leading cause of death among cancer patients. This
heterogeneous disease is characterized by alterations in multiple molecular pathways …

Objective: We postulated that the ImmunoScore (IS) could markedly improve the prediction
of postsurgical survival and chemotherapeutic benefits in gastric cancer (GC). Summary …

Molecular subtyping of cancer is a critical step towards more individualized therapy and
provides important biological insights into cancer heterogeneity. Although gene expression …

Tumor-infiltrating lymphocytes play an essential role in improving clinical outcome of
neuroblastoma (NB) patients, but their relationship with other tumor-infiltrating immune cells …

Background Current staging methods do not accurately predict the risk of disease
recurrence and benefit of adjuvant chemotherapy for patients who have had surgery for …

Background Precision cancer medicine depends on defining distinct tumour subgroups
using biomarkers that may occur at very modest frequencies. One such subgroup comprises …

MicroRNAs (miRNAs) are small, single-stranded, noncoding RNAs that can post-
transcriptionally regulate the expression of various oncogenes and tumor suppressor genes …

Background Increasing evidence has indicated an association between immune infiltration
in gastric cancer and clinical outcome. However, reliable prognostic signatures, based on …

Current staging systems of cancer are mainly based on the anatomical extent of disease.
They need refinement by biological parameters to improve stratification of patients for tumor …