Actin polymerization generates forces for cellular processes throughout the eukaryotic
kingdom, but our understanding of the 'ancient'actin turnover machineries is limited. We …

Abstract Profilin-1 (PFN1) is a cytoskeletal protein that regulates the dynamics of actin and
microtubule assembly. Thus, PFN1 is essential for the normal division, motility, and …

Diseases caused by Leishmania and Trypanosoma parasites are a major health problem in
tropical countries. Because of their complex life cycle involving both vertebrate and insect …

The precise assembly and disassembly of actin filaments is required for several cellular
processes, and their regulation has been scrutinized for decades. Twenty years ago, a …

In order to decipher the complex molecular mechanisms that regulate the assembly and
disassembly of actin filaments, it is a great asset to monitor individual reactions live in well …

With the increased appreciation of the biological relevance of pseudokinase (PSK) allostery,
the broadening of small molecule strategies to target PSK function is of particular …

Although β-actin is one of only two ubiquitously expressed actin isoforms present in all cells,
it remains understudied biochemically due to technical challenges associated with protein …

Diseases caused by Leishmania, and Trypanosoma parasites, such as leishmaniasis and
African sleeping sickness, are a major health problem in tropical countries. Due to their …

Actin is one of the most abundant and important proteins in the eukaryotic cell. The self-
assembly and the ATP hydrolysis are the two key activities of actin, which are linked forming …