The discovery of insulin in 1921 has been one of greatest scientific achievements of the 20th
century. Since then, the availability of insulin has shifted the focus of diabetes treatment from …

This review focuses on the human pancreatic islet—including its structure, cell composition,
development, function, and dysfunction. After providing a historical timeline of key …

Aging increases the susceptibility to a diverse set of diseases and disorders, including
neurodegeneration, cancer, diabetes, and arthritis. Natural compounds are currently being …

Diabetes mellitus is a pandemic metabolic disorder that results from either the autoimmune
destruction or the dysfunction of insulin-producing pancreatic beta cells. A promising cure is …

NEUROD1 is a transcription factor that helps maintain a mature phenotype of pancreatic β
cells. Disruption of Neurod1 during pancreatic development causes severe neonatal …

Diabetes is a metabolic disease that involves the death or dysfunction of the insulin-
secreting β cells in the pancreas. Consequently, most diabetes research is aimed at …

Pancreatic cancer is a very aggressive disease with 5-year survival rates of less than 10%.
The constantly increasing incidence and stagnant patient outcomes despite changes in …

Organoids have become one of the fastest progressing and applied models in biological
and medical research, and various organoids have now been developed for most of the …

Various important transcription factors in the pancreas are involved in the process of
pancreas development, the differentiation of endocrine progenitor cells into mature insulin …

Identifying genes linked to extreme phenotypes in humans has the potential to highlight
biological processes not shared with all other mammals. Here, we report the identification of …