Multi-omics data integration, interpretation, and its application

I Subramanian, S Verma, S Kumar… - … and biology insights, 2020 - journals.sagepub.com
To study complex biological processes holistically, it is imperative to take an integrative
approach that combines multi-omics data to highlight the interrelationships of the involved …

[HTML][HTML] Methodological and quality flaws in the use of artificial intelligence in mental health research: systematic review

R Tornero-Costa, A Martinez-Millana… - JMIR Mental …, 2023 - mental.jmir.org
Background: Artificial intelligence (AI) is giving rise to a revolution in medicine and health
care. Mental health conditions are highly prevalent in many countries, and the COVID-19 …

Global evolution of research in artificial intelligence in health and medicine: a bibliometric study

BX Tran, GT Vu, GH Ha, QH Vuong, MT Ho… - Journal of clinical …, 2019 - mdpi.com
The increasing application of Artificial Intelligence (AI) in health and medicine has attracted
a great deal of research interest in recent decades. This study aims to provide a global and …

Dealing with dimensionality: the application of machine learning to multi-omics data

D Feldner-Busztin, P Firbas Nisantzis… - …, 2023 - academic.oup.com
Motivation Machine learning (ML) methods are motivated by the need to automate
information extraction from large datasets in order to support human users in data-driven …

Metabolomics and multi-omics integration: a survey of computational methods and resources

T Eicher, G Kinnebrew, A Patt, K Spencer, K Ying, Q Ma… - Metabolites, 2020 - mdpi.com
As researchers are increasingly able to collect data on a large scale from multiple clinical
and omics modalities, multi-omics integration is becoming a critical component of …

Multi-omics data integration methods and their applications in psychiatric disorders

A Sathyanarayanan, TT Mueller, MA Moni… - European …, 2023 - Elsevier
To study mental illness and health, in the past researchers have often broken down their
complexity into individual subsystems (eg, genomics, transcriptomics, proteomics, clinical …

Pharmacometabonomics: data processing and statistical analysis

J Fu, Y Zhang, J Liu, X Lian, J Tang… - Briefings in …, 2021 - academic.oup.com
Individual variations in drug efficacy, side effects and adverse drug reactions are still
challenging that cannot be ignored in drug research and development. The aim of …

Challenges and future prospects of precision medicine in psychiatry

M Manchia, C Pisanu, A Squassina… - Pharmacogenomics …, 2020 - Taylor & Francis
Precision medicine is increasingly recognized as a promising approach to improve disease
treatment, taking into consideration the individual clinical and biological characteristics …

Exploring the role of gut microbiota in major depressive disorder and in treatment resistance to antidepressants

A Fontana, M Manchia, C Panebianco, P Paribello… - Biomedicines, 2020 - mdpi.com
Major depressive disorder (MDD) is a common severe psychiatric illness, exhibiting sub-
optimal response to existing pharmacological treatments. Although its etiopathogenesis is …

Multi-omics driven predictions of response to acute phase combination antidepressant therapy: a machine learning approach with cross-trial replication

JB Joyce, CW Grant, D Liu… - Translational …, 2021 - nature.com
Combination antidepressant pharmacotherapies are frequently used to treat major
depressive disorder (MDD). However, there is no evidence that machine learning …