[HTML][HTML] Drug discovery for cutaneous leishmaniasis: a review of developments in the past 15 years

HN Corman, CW McNamara, MA Bakowski - Microorganisms, 2023 - mdpi.com
Leishmaniasis is a group of vector-borne, parasitic diseases caused by over 20 species of
the protozoan Leishmania spp. The three major disease classifications, cutaneous, visceral …

An appraisal of the scientific current situation and new perspectives in the treatment of cutaneous leishmaniasis

CAB Nieva, AG Cid, AI Romero, MF García-Bustos… - Acta Tropica, 2021 - Elsevier
Abstract Leishmaniasis is a Neglected Tropical Diseases caused by protozoan parasites of
the genus Leishmania. It is a major health problem in many tropical and subtropical regions …

Efficacy of photodynamic therapy using TiO2 nanoparticles doped with Zn and hypericin in the treatment of cutaneous Leishmaniasis caused by Leishmania …

AAL Sepúlveda, AMA Velásquez, IAP Linares… - Photodiagnosis and …, 2020 - Elsevier
Since Leishmania parasites exhibit resistance outbreaks to drugs conventionally used in
medical treatments, research of new antileishmanial compounds or alternative treatment …

Development of New Leishmanicidal Compounds via Bioconjugation of Antimicrobial Peptides and Antileishmanial Guanidines

NCS Costa, LR Dos Anjos, JVM de Souza… - ACS …, 2023 - ACS Publications
Leishmaniasis refers to a collection of diseases caused by protozoa from the Leishmania
genus. These diseases, along with other parasitic afflictions, pose a significant public health …

[HTML][HTML] Novel Selective and Low-Toxic Inhibitor of LmCPB2.8ΔCTE (CPB) One Important Cysteine Protease for Leishmania Virulence

VP Moreira, MF da Silva Mela, LR Anjos, LF Saraiva… - Biomolecules, 2022 - mdpi.com
Leishmaniasis is a highly prevalent, yet neglected disease caused by protozoan parasites of
the genus Leishmania. In the search for newer, safer, and more effective antileishmanial …

[HTML][HTML] Antimicrobial activity of RP-1 peptide conjugate with ferrocene group

NCS Costa, JP Piccoli, NA Santos-Filho… - Plos one, 2020 - journals.plos.org
Parasitic diseases are a neglected and serious problem, especially in underdeveloped
countries. Among the major parasitic diseases, Leishmaniasis figures as an urgent …

Molecular-level strategic goals and repressors in Leishmaniasis–Integrated data to accelerate target-based heterocyclic scaffolds

M Abirami, BK Kumar, S Dey, S Johri… - European Journal of …, 2023 - Elsevier
Leishmaniasis is a complex of neglected tropical diseases caused by various species of
leishmanial parasites that primarily affect the world's poorest people. A limited number of …

Potent drug candidature of an ONS donor tethered copper (II) complex: Anticancer activity, cytotoxicity and spectroscopically approached BSA binding studies

M Kongot, D Reddy, V Singh, R Patel… - … Acta Part A: Molecular …, 2019 - Elsevier
In our continued efforts to develop metal based therapeutic agents, we have synthesized a
novel copper (II) complex,[{Cu (hpdbal-sbdt)} 2](2) tethered with a biocompatible ONS 2 …

Pd (II) complexes with N-heteroaromatic hydrazone ligands: Anticancer activity, in silico and experimental target identification

SK Bjelogrlić, TR Todorović, M Kojić… - Journal of inorganic …, 2019 - Elsevier
Anticancer activity of Pd complexes 1–5 with bidentate N-heteroaromatic hydrazone ligands
was investigated on human acute monocytic leukemia (THP-1; cells in a suspension) and …

Development of dextrin-amphotericin B formulations for the treatment of Leishmaniasis

R Silva-Carvalho, J Fidalgo, KR Melo… - International journal of …, 2020 - Elsevier
The most effective medicines available for the treatment of leishmaniasis, a life-threatening
disease, exhibit serious toxicological issues. To achieve better therapeutic efficiency while …