Structure determination of the HIV‐1 envelope glycoprotein (Env) presented a number of
challenges, but several high‐resolution structures have now become available. In 2013 …

We describe the development and potential use of various designs of recombinant HIV‐1
envelope glycoprotein trimers that mimic the structure of the virion‐associated spike, which …

Severe acute respiratory syndrome coronavirus (SARS-CoV) emerged in 2002 as a highly
transmissible pathogenic human betacoronavirus. The viral spike glycoprotein (S) utilizes …

A desirable but as yet unachieved property of a human immunodeficiency virus type 1 (HIV-
1) vaccine candidate is the ability to induce broadly neutralizing antibodies (bNAbs). One …

The HIV-1 envelope glycoprotein (Env) trimer contains the receptor binding sites and
membrane fusion machinery that introduce the viral genome into the host cell. As the only …

HIV-1 entry into CD4+ target cells is mediated by cleaved envelope glycoprotein (Env)
trimers that have been challenging to characterize structurally. Here, we describe the crystal …

The HIV-1 envelope glycoprotein trimer is covered by an array of N-linked glycans that
shield it from immune surveillance. The high density of glycans on the trimer surface …

All previously characterized broadly neutralizing antibodies to the HIV-1 envelope
glycoprotein (Env) target one of four major sites of vulnerability. Here, we define and …

Recombinant trimeric mimics of the human immunodeficiency virus type 1 (HIV-1) envelope
glycoprotein (Env) spike should expose as many epitopes as possible for broadly …

Viral glycoproteins mediate entry by pH-activated or receptor-engaged activation and exist
in metastable pre-fusogenic states that may be stabilized by directed rational design. As …