Found throughout biology, polyvalent interactions are characterized by the simultaneous
binding of multiple ligands on one biological entity to multiple receptors on another (top part …

Überall in der Biologie kommen polyvalente Wechselwirkungen vor. Sie zeichnen sich
durch die gleichzeitige Bindung mehrerer Liganden einer biologischen Einheit an mehrere …

Human basophils are important tools for studying immediate-type hypersensitivity reactions
since they release a variety of mediators (eg, histamine, leukotriene C4, IL-4 and IL-13) …

We present a general mathematical analysis of the problem of bivalent ligands, containing
two identical reactive groups, interacting with cell surface receptors. The initial binding of …

Mast cells are effector cells of the innate immune system, but because they express Fc
receptors (FcRs), they can be engaged in adaptive immunity by antibodies. Mast cell FcRs …

Basophils from approximately one fifth of the population were found to be unresponsive
(nonreleasers), in terms of both histamine and leukotriene release, to an IgE cross-linking …

Cell activation results from the transient displacement of an active balance between positive
and negative signaling. This displacement depends in part on the engagement of cell …

Background Immune responses to N‐glycan structures from allergens and parasites are
often associated with pronounced, high affinity IgE reactivities. Cross‐reactive carbohydrate …

Publisher Summary This chapter establishes that the Fc fragment of immunoglobulins E
(IgE) binds with high affinity to specific cell surface receptors (FcɛR) on basophils and mast …

The interaction of multivalent ligand with cell surface receptors is the first step in triggering a
number of biological responses. Here I present and analyze a mathematical model for the …