Phase separation of biological molecules, such as nucleic acids and proteins, has garnered
widespread attention across many fields in recent years. For instance, liquid-liquid phase …

Liquid-liquid phase separation (LLPS) of proteins and nucleic acids has emerged as an
important phenomenon in membraneless intracellular organization. We demonstrate that the …

Aberrant cell fate decisions due to transcriptional misregulation are central to malignant
transformation. Histones are the major constituents of chromatin, and mutations in histone …

Fluorescent proteins have been widely used in biology because of their compatibility and
varied applications in living specimens. Fluorescent proteins are often undesirably sensitive …

Raster image correlation spectroscopy (RICS) is a powerful method for measuring molecular
diffusion in live cells directly from images acquired on a laser scanning microscope …

Epstein-Barr virus (EBV) uses a biphasic lifecycle of latency and lytic reactivation to infect>
95% of adults worldwide. Despite its central role in EBV persistence and oncogenesis, much …

The H1 or linker histones bind dynamically to chromatin in living cells via a process that
involves transient association with the nucleosome near the DNA entry/exit site followed by …

Chromatin accessibility is modulated in a variety of ways to create open and closed
chromatin states, both of which are critical for eukaryotic gene regulation. At the single …

In this review, the structural aspects of linker H1 histones are presented as a background for
characterization of the factors influencing their function in animal and human chromatin. The …

Gene expression is subject to stochastic noise, but to what extent and by which means such
stochastic variations are coordinated among different genes are unclear. We hypothesize …