Principles and methods for transferring polygenic risk scores across global populations
Polygenic risk scores (PRSs) summarize the genetic predisposition of a complex human trait
or disease and may become a valuable tool for advancing precision medicine. However …
or disease and may become a valuable tool for advancing precision medicine. However …
Genomic selection in plant breeding: methods, models, and perspectives
Genomic selection (GS) facilitates the rapid selection of superior genotypes and accelerates
the breeding cycle. In this review, we discuss the history, principles, and basis of GS and …
the breeding cycle. In this review, we discuss the history, principles, and basis of GS and …
Polygenic scoring accuracy varies across the genetic ancestry continuum
Polygenic scores (PGSs) have limited portability across different groupings of individuals (for
example, by genetic ancestries and/or social determinants of health), preventing their …
example, by genetic ancestries and/or social determinants of health), preventing their …
Theoretical and empirical quantification of the accuracy of polygenic scores in ancestry divergent populations
Polygenic scores (PGS) have been widely used to predict disease risk using variants
identified from genome-wide association studies (GWAS). To date, most GWAS have been …
identified from genome-wide association studies (GWAS). To date, most GWAS have been …
[HTML][HTML] Breeding schemes for the implementation of genomic selection in wheat (Triticum spp.)
In the last decade the breeding technology referred to as 'genomic selection'(GS) has been
implemented in a variety of species, with particular success in animal breeding. Recent …
implemented in a variety of species, with particular success in animal breeding. Recent …
Training set optimization under population structure in genomic selection
Key message Population structure must be evaluated before optimization of the training set
population. Maximizing the phenotypic variance captured by the training set is important for …
population. Maximizing the phenotypic variance captured by the training set is important for …
Genomic prediction in animals and plants: simulation of data, validation, reporting, and benchmarking
HD Daetwyler, MPL Calus, R Pong-Wong… - Genetics, 2013 - academic.oup.com
The genomic prediction of phenotypes and breeding values in animals and plants has
developed rapidly into its own research field. Results of genomic prediction studies are often …
developed rapidly into its own research field. Results of genomic prediction studies are often …
Genomic selection and its research progress in aquaculture breeding
H Song, T Dong, X Yan, W Wang, Z Tian… - Reviews in …, 2023 - Wiley Online Library
Since its introduction in 2001, genomic selection (GS) has progressed rapidly. As a research
and application hot topic, GS has led to a revolution in the field of animal and plant breeding …
and application hot topic, GS has led to a revolution in the field of animal and plant breeding …
Integrated genomic selection for accelerating breeding programs of climate-smart cereals
Rapidly rising population and climate changes are two critical issues that require immediate
action to achieve sustainable development goals. The rising population is posing increased …
action to achieve sustainable development goals. The rising population is posing increased …
Invited review: overview of new traits and phenotyping strategies in dairy cattle with a focus on functional traits
For several decades, breeding goals in dairy cattle focussed on increased milk production.
However, many functional traits have negative genetic correlations with milk yield, and …
However, many functional traits have negative genetic correlations with milk yield, and …