Changing landscape of congenital heart disease

BJ Bouma, BJM Mulder - Circulation research, 2017 - Am Heart Assoc
Congenital heart disease is the most frequently occurring congenital disorder affecting≈
0.8% of live births. Thanks to great efforts and technical improvements, including the …

The role of imaging of flow patterns by 4D flow MRI in aortic stenosis

J Garcia, AJ Barker, M Markl - JACC: Cardiovascular Imaging, 2019 - jacc.org
Aortic valve stenosis (AS) is the most prevalent valvular heart disease in developed
countries and is associated with the development of severe secondary complications such …

Aortic valve stenosis alters expression of regional aortic wall shear stress: New insights from a 4‐dimensional flow magnetic resonance imaging study of 571 subjects

P Van Ooij, M Markl, JD Collins, JC Carr… - Journal of the …, 2017 - Am Heart Assoc
Background Wall shear stress (WSS) is a stimulus for vessel wall remodeling. Differences in
ascending aorta (AA o) hemodynamics have been reported between bicuspid aortic valve …

Association of regional wall shear stress and progressive ascending aorta dilation in bicuspid aortic valve

G Soulat, MB Scott, BD Allen, R Avery, RO Bonow… - Cardiovascular …, 2022 - jacc.org
Objectives The aim of this study was to evaluate the role of wall shear stress (WSS) as a
predictor of ascending aorta (AAo) growth at 5 years or greater follow-up. Background Aortic …

4D Flow with MRI

G Soulat, P McCarthy, M Markl - Annual review of biomedical …, 2020 - annualreviews.org
Magnetic resonance imaging (MRI) has become an important tool for the clinical evaluation
of patients with cardiac and vascular diseases. Since its introduction in the late 1980s …

Evaluation of aortic blood flow and wall shear stress in aortic stenosis and its association with left ventricular remodeling

F von Knobelsdorff-Brenkenhoff… - Circulation …, 2016 - Am Heart Assoc
Background—Aortic stenosis (AS) leads to variable stress for the left ventricle (LV) and
consequently a broad range of LV remodeling. The aim of this study was to describe blood …

4D flow MRI applications in congenital heart disease

J Rizk - European Radiology, 2021 - Springer
Advances in the diagnosis and management of congenital heart disease (CHD) have
resulted in a growing population of patients surviving well into adulthood and requiring …

Pathogenic mechanisms of bicuspid aortic valve aortopathy

NM Yassine, JT Shahram, SC Body - Frontiers in physiology, 2017 - frontiersin.org
Bicuspid aortic valve (BAV) is the most common congenital valvular defect and is associated
with ascending aortic dilation (AAD) in a quarter of patients. AAD has been ascribed both to …

Cardiovascular disease in ageing: an overview on thoracic aortic aneurysm as an emerging inflammatory disease

C Pisano, CR Balistreri, A Ricasoli… - Mediators of …, 2017 - Wiley Online Library
Medial degeneration associated with thoracic aortic aneurysm and acute aortic dissection
was originally described by Erdheim as a noninflammatory lesion related to the loss of …

Age-related vascular changes affect turbulence in aortic blood flow

H Ha, M Ziegler, M Welander, N Bjarnegård… - Frontiers in …, 2018 - frontiersin.org
Turbulent blood flow is implicated in the pathogenesis of several aortic diseases but the
extent and degree of turbulent blood flow in the normal aorta is unknown. We aimed to …