Disturbed cholesterol homeostasis plays critical roles in the development of multiple
diseases, such as cardiovascular diseases (CVD), neurodegenerative diseases and …

The immune system protects the body against harm by inducing inflammation. During the
immune response, cells of the immune system get activated, divided and differentiated in …

Incomplete understanding of how hepatosteatosis transitions to fibrotic non-alcoholic
steatohepatitis (NASH) has limited therapeutic options. Two molecules that are elevated in …

Assemblies of tau can transit between neurons, seeding aggregation in a prion-like manner.
To accomplish this, tau must cross cell-limiting membranes, a process that is poorly …

Alveolar macrophages (AM) play a central role in initiation and resolution of lung
inflammation, but the integration of these opposing core functions is poorly understood. AM …

CSF-1R haploinsufficiency causes adult-onset leukoencephalopathy with axonal spheroids
and pigmented glia (ALSP). Previous studies in the Csf1r+/− mouse model of ALSP …

Oxysterols are derivatives of cholesterol and an important regulator of cholesterol
metabolism, in part due to their role as ligands for nuclear receptors, such as the liver X …

Objective Expansion of visceral adipose tissue (VAT) and metabolic inflammation are
consequences of obesity and associated with type 2 diabetes (T2DM). Metabolically …

As an essential lipid, cholesterol is of great value in keeping cell homeostasis, being the
precursor of bile acid and steroid hormones, and stabilizing membrane lipid rafts. As a kind …

Targeting autophagy is a promising therapeutic approach in cancer therapy. Here, we
screened 30 traditional herbal medicines to identify novel autophagy regulators and found …