Developing networks follow common rules to shift from silent cells to coactive networks that
operate via thousands of synapses. This review deals with some of these rules and in …

Recent years have witnessed a steep increase in studies on the diverse roles of neuronal
cation-chloride cotransporters (CCCs). The versatility of CCC gene transcription …

Extended wakefulness is associated with reduced performance and the build-up of sleep
pressure. In the cortex, this manifests as changes in network activity. These changes show …

Human-induced pluripotent stem cells (hiPSCs) can differentiate into functional
cardiomyocytes; however, the electrophysiological properties of hiPSC-derived …

Dopaminergic (DA) signaling governs the control of complex behaviors, and its deregulation
has been implicated in a wide range of diseases. Here we demonstrate that inactivation of …

Abstract Pro-opiomelanocortin (POMC)-expressing neurons in the arcuate nucleus of the
hypothalamus represent key regulators of metabolic homeostasis. Electrophysiological and …

We have found that, during the early stages of cortical neurogenesis, both GABA and
glutamate depolarize cells in the ventricular zone of rat embryonic neocortex. In the …

Background—Drug-induced arrhythmia is one of the most common causes of drug
development failure and withdrawal from market. This study tested whether human induced …

Synaptic inhibition plays a crucial role in regulating neuronal excitability, which is the
foundation of nervous system function. This inhibition is largely mediated by the …

Substantia nigra dopamine neurons have been implicated in the initiation and invigoration
of movement, presumably through their modulation of striatal projection neuron (SPN) …