[HTML][HTML] Pharmaceutical cocrystals: A review of preparations, physicochemical properties and applications
M Guo, X Sun, J Chen, T Cai - Acta Pharmaceutica Sinica B, 2021 - Elsevier
Pharmaceutical cocrystals are multicomponent systems in which at least one component is
an active pharmaceutical ingredient and the others are pharmaceutically acceptable …
an active pharmaceutical ingredient and the others are pharmaceutically acceptable …
Mechanical Activation by Ball Milling as a Strategy to Prepare Highly Soluble Pharmaceutical Formulations in the Form of Co-Amorphous, Co-Crystals, or Polymorphs
LM Martínez, J Cruz-Angeles, M Vázquez-Dávila… - Pharmaceutics, 2022 - mdpi.com
Almost half of orally administered active pharmaceutical ingredients (APIs) have low
solubility, which affects their bioavailability. In the last two decades, several alternatives …
solubility, which affects their bioavailability. In the last two decades, several alternatives …
Discovered two polymorphs and two solvates of lamotrigine-tolfenamic acid salt: Thermal behavior and crystal morphological differences
J Li, Y Huang, Q An, W Li, J Li, H Liu, D Yang… - International Journal of …, 2022 - Elsevier
Multi-component pharmaceutical systems such as cocrystal and salt have gained popularity
in academia and industry due to their ability to regulate the poor physicochemical properties …
in academia and industry due to their ability to regulate the poor physicochemical properties …
Structural landscape on a series of rhein: Berberine cocrystal salt solvates: The formation, dissolution elucidation from experimental and theoretical investigations
D Yang, H Wang, Q Liu, P Yuan, T Chen, L Zhang… - Chinese Chemical …, 2022 - Elsevier
The specific crystalline form of a compound remarkably affects its physicochemical
properties. Therefore, a detailed analysis of the structural features and intermolecular …
properties. Therefore, a detailed analysis of the structural features and intermolecular …
Improving the dissolution behaviors and bioavailability of abiraterone acetate via multicomponent crystal forms
Z Yang, Y Yang, M Xia, W Dai, B Zhu, X Mei - International Journal of …, 2022 - Elsevier
Abiraterone acetate (ABA), the first-line drug for the treatment of metastatic castration
resistant prostate cancer (mCRPC), is administered at a high daily dosage of 1000 mg due …
resistant prostate cancer (mCRPC), is administered at a high daily dosage of 1000 mg due …
Novel drug-drug salts of enoxacin with enhanced antibacterial activity: Insights from solubility and lipid-water partition coefficient
J Li, S Song, W Huang, H Fan, Z Zhou - Journal of Molecular Liquids, 2023 - Elsevier
Abstract Enoxacin (ENX), a third-generation fluoroquinolone, demonstrates broad-spectrum
antibacterial activities and is widely applied for the treatment of various bacterial infections …
antibacterial activities and is widely applied for the treatment of various bacterial infections …
Pharmaceutical cocrystal: a game changing approach for the administration of old drugs in new crystalline form
PS Panzade, GR Shendarkar - Drug development and industrial …, 2020 - Taylor & Francis
Pharmaceutical cocrystals are still gaining the interest of the researchers due to their
potential to alter physicochemical, mechanical, and pharmacokinetic properties of active …
potential to alter physicochemical, mechanical, and pharmacokinetic properties of active …
[HTML][HTML] Preparation, characterization, and pharmacokinetics of rivaroxaban cocrystals with enhanced in vitro and in vivo properties in beagle dogs
Y Meng, F Tan, J Yao, Y Cui, Y Feng, Z Li… - International Journal of …, 2022 - Elsevier
Rivaroxaban (RIV) is a direct Factor Xa inhibitor anticoagulant, but the oral bioavailability of
RIV is estimated to be only 60% due to its poor solubility. The aim of the present study was to …
RIV is estimated to be only 60% due to its poor solubility. The aim of the present study was to …
Two cocrystals of olaparib with flavonoids toward sustained release: structure, dissolution behavior, and anticancer activity analysis
C Duan, Y Chen, Y Zhang, F Liang, W Liu… - Crystal Growth & …, 2022 - ACS Publications
As the first FDA-approved PARP1/2 inhibitor, olaparib (OLA) is a blockbuster anticancer
drug, but its use has been limited by the dose-limiting toxicity and short half life of …
drug, but its use has been limited by the dose-limiting toxicity and short half life of …
Phase solubility investigation and theoretical calculations on drug-drug cocrystals of carbamazepine with Emodin, Paeonol
Abstract Carbamazepine (CBZ), a Biopharmaceutics Classification System (BCS) class II
drug, is widely-used as a first line antiepileptic drug. Numbers of cocrystals have reported to …
drug, is widely-used as a first line antiepileptic drug. Numbers of cocrystals have reported to …