Transcriptional control of ribosome biogenesis in yeast: links to growth and stress signals
D Shore, S Zencir, B Albert - Biochemical Society Transactions, 2021 - portlandpress.com
Ribosome biogenesis requires prodigious transcriptional output in rapidly growing yeast
cells and is highly regulated in response to both growth and stress signals. This minireview …
cells and is highly regulated in response to both growth and stress signals. This minireview …
Chromatin three-dimensional interactions mediate genetic effects on gene expression
INTRODUCTION Genome-wide studies on the genetic basis of gene expression have
advanced considerably our understanding of the function of the human genome. Large …
advanced considerably our understanding of the function of the human genome. Large …
Regulatory mechanisms ensuring coordinated expression of functionally related genes
Coordinated spatiotemporal expression of large sets of genes is required for the
development and homeostasis of organisms. To achieve this goal, organisms use myriad …
development and homeostasis of organisms. To achieve this goal, organisms use myriad …
Divergent expression of paralogous genes by modification of shared enhancer activity through a promoter-proximal silencer
R Loker, RS Mann - Current Biology, 2022 - cell.com
The duplication of genes and their associated cis-regulatory elements, or enhancers, is a
key contributor to genome evolution and biological complexity. Moreover, many paralogs …
key contributor to genome evolution and biological complexity. Moreover, many paralogs …
Gene clustering and copy number variation in alkaloid metabolic pathways of opium poppy
Q Li, S Ramasamy, P Singh, JM Hagel… - Nature …, 2020 - nature.com
Genes in plant secondary metabolic pathways enable biosynthesis of a range of medically
and industrially important compounds, and are often clustered on chromosomes. Here, we …
and industrially important compounds, and are often clustered on chromosomes. Here, we …
Synthetic analysis of chromatin tracing and live-cell imaging indicates pervasive spatial coupling between genes
The role of the spatial organization of chromosomes in directing transcription remains an
outstanding question in gene regulation. Here, we analyze two recent single-cell imaging …
outstanding question in gene regulation. Here, we analyze two recent single-cell imaging …
[HTML][HTML] RNA Pol II length and disorder enable cooperative scaling of transcriptional bursting
Summary RNA polymerase II (RNA Pol II) contains a disordered C-terminal domain (CTD)
whose length enigmatically correlates with genome size. The CTD is crucial to eukaryotic …
whose length enigmatically correlates with genome size. The CTD is crucial to eukaryotic …
Efficient weighted univariate clustering maps outstanding dysregulated genomic zones in human cancers
Motivation Chromosomal patterning of gene expression in cancer can arise from
aneuploidy, genome disorganization or abnormal DNA methylation. To map such patterns …
aneuploidy, genome disorganization or abnormal DNA methylation. To map such patterns …
A cGAL-UAS bipartite expression toolkit for Caenorhabditis elegans sensory neurons
Animals integrate sensory information from the environment and display various behaviors
in response to external stimuli. In Caenorhabditis elegans hermaphrodites, 33 types of …
in response to external stimuli. In Caenorhabditis elegans hermaphrodites, 33 types of …
Signal integration by shadow enhancers and enhancer duplications varies across the Drosophila embryo
Transcription of developmental genes is controlled by multiple enhancers. Frequently, more
than one enhancer can activate transcription from the same promoter in the same cells. How …
than one enhancer can activate transcription from the same promoter in the same cells. How …