Following their exit from the thymus, T cells are endowed with potent effector functions but
must spare host tissue from harm. The fate of these cells is dictated by a series of …

T cells are a central component of defenses against pathogens and tumors. Their effector
functions are sustained by specific metabolic changes that occur upon activation, and these …

Despite the importance of memory B cells in protection from reinfection, how such memory
cells are selected and generated during germinal-center (GC) reactions remains unclear …

Abstract Naive CD4+ and CD8+ T cells undergo unique developmental programs after
activation, resulting in the generation of effector and long-lived memory T cells. Recent …

During the course of an immune response, antigen-reactive T cells clonally expand and then
are removed by apoptosis to maintain immune homeostasis. Life and death of T cells is …

Cytokines, particularly those of the common γ chain receptor family, provide extrinsic signals
that regulate naive CD4 cell survival. Whether these cytokines are required for the …

Natural killer T (NKT) cells recognize glycolipid antigens presented by the MHC class I–
related glycoprotein CD1d. The in vivo dynamics of the NKT cell population in response to …

Although the presence of a BH4 domain distinguishes the antiapoptotic protein Bcl-2 from its
proapoptotic relatives, little is known about its function. BH4 deletion converts Bcl-2 into a …

Toll-like receptor (TLR) engagement by pathogen-associated molecular patterns (PAMPs) is
an important mechanism for optimal cellular immune responses. APC TLR engagement …

The book aims to provide an introduction to mathematical models that describe the
dynamics of tumor growth and the evolution of tumor cells. It can be used as a textbook for …