Speaking the host language: how Salmonella effector proteins manipulate the host

TD Pillay, SU Hettiarachchi, J Gan… - …, 2023 - microbiologyresearch.org
Salmonella injects over 40 virulence factors, termed effectors, into host cells to subvert
diverse host cellular processes. Of these 40 Salmonella effectors, at least 25 have been …

Salmonella: infection mechanism and control strategies

J Lu, H Wu, S Wu, S Wang, H Fan, H Ruan, J Qiao… - Microbiological …, 2024 - Elsevier
Salmonella is a foodborne pathogen that predominantly resides in the intestinal tract of
humans and animals. Infections caused by Salmonella can lead to various illnesses …

Dual-sgRNA CRISPRa System for Enhanced MK-7 Production and Salmonella Infection Mitigation in Bacillus subtilis natto Applied to Caco-2 Cells

C Liao, J Cui, M Gao, B Wang, K Ito… - Journal of Agricultural …, 2024 - ACS Publications
This study optimized the menaquinone-7 (MK-7) synthetic pathways in Bacillus subtilis (B.
subtilis) natto NB205, a strain that originated from natto, to enhance its MK-7 production …

Salmonella enterica serovar Typhi uses two type 3 secretion systems to replicate in human macrophages and colonize humanized mice

M Hamblin, R Schade, R Narasimhan, DM Monack - MBio, 2023 - Am Soc Microbiol
Salmonella enterica serovar Typhi (S. Typhi) is a human-restricted pathogen that replicates
in macrophages. In this study, we investigated the roles of the S. Typhi type 3 secretion …

Virulence and Antimicrobial‐Resistant Gene Profiles of Salmonella spp. Isolates from Chicken Carcasses Markets in Ibague City, Colombia

KJ Lozano-Villegas… - International Journal of …, 2024 - Wiley Online Library
Salmonella spp. is one of the leading causes of foodborne bacterial infections, with major
impacts on public health and healthcare system. Salmonella is commonly transmitted via the …

SaaS sRNA promotes Salmonella intestinal invasion via modulating MAPK inflammatory pathway

L Cai, Y Xie, L Shao, H Hu, X Xu, H Wang, G Zhou - Gut Microbes, 2023 - Taylor & Francis
Salmonella Enteritidis is a foodborne enteric pathogen that infects humans and animals,
utilizing complex survival strategies. Bacterial small RNA (sRNA) plays an important role in …

Vimentin cage–A double-edged sword in host anti-infection defense

S Zhao, C Miao, X Gao, Z Li, JE Eriksson… - Current Opinion in Cell …, 2024 - Elsevier
Vimentin, a type III intermediate filament, reorganizes into what is termed the 'vimentin
cage'in response to various pathogenic infections. This cage-like structure provides an …

Japanese encephalitis virus NS1 and NS1'proteins induce vimentin rearrangement via the CDK1-PLK1 axis to promote viral replication

S Xie, X Yang, X Yang, Z Cao, N Wei, X Lin… - Journal of …, 2024 - Am Soc Microbiol
The host cytoskeleton plays crucial roles in various stages of virus infection, including viral
entry, transport, replication, and release. However, the specific mechanisms by which …

Discovery of Trametinib as an orchestrator for cytoskeletal vimentin remodeling

S Zhao, Z Li, Q Zhang, Y Zhang, J Zhang… - Journal of Molecular …, 2024 - academic.oup.com
The dynamic remodeling of the cytoskeletal network of vimentin intermediate filaments
network supports various cellular functions, including cell morphology, elasticity, migration …

EGFR-MEK1/2 cascade negatively regulates bactericidal function of bone marrow macrophages in mice with Staphylococcus aureus osteomyelitis

M Jin, X Wu, J Hu, Y Chen, B Yang, C Cheng… - Plos …, 2024 - journals.plos.org
The ability of Staphylococcus aureus (S. aureus) to survive within macrophages is a critical
strategy for immune evasion, contributing to the pathogenesis and progression of …