Thrombocytopathy and endotheliopathy: crucial contributors to COVID-19 thromboinflammation
The core pathology of coronavirus disease 2019 (COVID-19) is infection of airway cells by
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that results in excessive …
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that results in excessive …
Mitochondria and microbiota dysfunction in COVID-19 pathogenesis
The COVID-19 pandemic caused by the coronavirus (SARS-CoV-2) has taken the world by
surprise into a major crisis of overwhelming morbidity and mortality. This highly infectious …
surprise into a major crisis of overwhelming morbidity and mortality. This highly infectious …
Platelets facilitate the wound-healing capability of mesenchymal stem cells by mitochondrial transfer and metabolic reprogramming
J Levoux, A Prola, P Lafuste, M Gervais, N Chevallier… - Cell metabolism, 2021 - cell.com
Platelets are known to enhance the wound-healing activity of mesenchymal stem cells
(MSCs). However, the mechanism by which platelets improve the therapeutic potential of …
(MSCs). However, the mechanism by which platelets improve the therapeutic potential of …
Comprehensive multi-omics analysis reveals mitochondrial stress as a central biological hub for spaceflight impact
Spaceflight is known to impose changes on human physiology with unknown molecular
etiologies. To reveal these causes, we used a multi-omics, systems biology analytical …
etiologies. To reveal these causes, we used a multi-omics, systems biology analytical …
MTH1 protects platelet mitochondria from oxidative damage and regulates platelet function and thrombosis
Y Ding, X Gui, X Chu, Y Sun, S Zhang, H Tong… - Nature …, 2023 - nature.com
Abstract Human MutT Homolog 1 (MTH1) is a nucleotide pool sanitization enzyme that
hydrolyzes oxidized nucleotides to prevent their mis-incorporation into DNA under oxidative …
hydrolyzes oxidized nucleotides to prevent their mis-incorporation into DNA under oxidative …
SARS-CoV-2 infection and oxidative stress: Pathophysiological insight into thrombosis and therapeutic opportunities
MS Alam, DM Czajkowsky - Cytokine & Growth Factor Reviews, 2022 - Elsevier
The current coronavirus disease 2019 (COVID-19) pandemic has presented unprecedented
challenges to global health. Although the majority of COVID-19 patients exhibit mild-to-no …
challenges to global health. Although the majority of COVID-19 patients exhibit mild-to-no …
Blood mitochondrial DNA copy number: what are we counting?
M Picard - Mitochondrion, 2021 - Elsevier
There is growing scientific interest to develop scalable biological measures that capture
mitochondrial (dys) function. Mitochondria have their own genome, the mitochondrial DNA …
mitochondrial (dys) function. Mitochondria have their own genome, the mitochondrial DNA …
Understanding long COVID; mitochondrial health and adaptation—old pathways, new problems
Many people infected with the SARS-CoV-2 suffer long-term symptoms, such as “brain fog”,
fatigue and clotting problems. Explanations for “long COVID” include immune imbalance …
fatigue and clotting problems. Explanations for “long COVID” include immune imbalance …
Expanding applications of allogeneic platelets, platelet lysates, and platelet extracellular vesicles in cell therapy, regenerative medicine, and targeted drug delivery
Platelets are small anucleated blood cells primarily known for their vital hemostatic role.
Allogeneic platelet concentrates (PCs) collected from healthy donors are an essential …
Allogeneic platelet concentrates (PCs) collected from healthy donors are an essential …
Redefining oxidative stress in Alzheimer's disease: Targeting platelet reactive oxygen species for novel therapeutic options
Abstract Alzheimer's disease (AD), a progressive neurodegenerative disorder, is considered
one of the most common causes of dementia worldwide, accounting for about 80% of all …
one of the most common causes of dementia worldwide, accounting for about 80% of all …