Neuroinflammation in Alzheimer's disease

IG Onyango, GV Jauregui, M Čarná, JP Bennett Jr… - Biomedicines, 2021 - mdpi.com
Alzheimer's disease (AD) is a neurodegenerative disease associated with human aging.
Ten percent of individuals over 65 years have AD and its prevalence continues to rise with …

[HTML][HTML] Natural sweetener Stevia rebaudiana: Functionalities, health benefits and potential risks

V Peteliuk, L Rybchuk, M Bayliak, KB Storey… - EXCLI …, 2021 - ncbi.nlm.nih.gov
Stevia rebaudiana is a South American plant, the cultivation of which is increasing
worldwide due to its high content of sweet compounds. Stevia sweetness is mainly due to …

Neuroprotective potentials of flavonoids: Experimental studies and mechanisms of action

P Bellavite - Antioxidants, 2023 - mdpi.com
Neurological and neurodegenerative diseases, particularly those related to aging, are on
the rise, but drug therapies are rarely curative. Functional disorders and the organic …

Multi-target mechanisms of phytochemicals in Alzheimer's disease: Effects on oxidative stress, neuroinflammation and protein aggregation

J Sharifi-Rad, S Rapposelli, S Sestito… - Journal of Personalized …, 2022 - mdpi.com
Alzheimer's disease (AD) is a neurodegenerative disease characterized by a tangle-shaped
accumulation of beta-amyloid peptide fragments and Tau protein in brain neurons. The …

Resveratrol attenuates rotenone-induced inflammation and oxidative stress via STAT1 and Nrf2/Keap1/SLC7A11 pathway in a microglia cell line

W Sun, H Li, Y Shen, H Xiao - Pathology-Research and Practice, 2021 - Elsevier
Scope Resveratrol is abundant in grapes. A protective role for resveratrol in anti-oxidation
and anti-inflammatory has been demonstrated. Rotenone is a pesticide, used to make …

Neuroprotective effects of phytochemicals against aluminum chloride-induced Alzheimer's disease through ApoE4/LRP1, wnt3/β-catenin/gsk3β, and TLR4/NLRP3 …

AME Hamdan, FHJ Alharthi, AH Alanazi, SZ El-Emam… - Pharmaceuticals, 2022 - mdpi.com
Background: Alzheimer's disease (AD) is a neurodegenerative disorder that is associated
with abnormal cognition. AD is aided in its initiation and progression by hereditary and …

Signaling mechanisms underlying inhibition of neuroinflammation by resveratrol in neurodegenerative diseases

J Huang, N Huang, S Xu, Y Luo, Y Li, H Jin… - The Journal of nutritional …, 2021 - Elsevier
Abstract Neurodegenerative diseases (NDs), including Alzheimer's disease (AD), and
Parkinson's disease (PD), are characterized by the progressive loss of the structure and …

[HTML][HTML] How can we modulate aging through nutrition and physical exercise? An epigenetic approach

AT Rajado, N Silva, F Esteves, D Brito, A Binnie… - Aging (Albany …, 2023 - ncbi.nlm.nih.gov
Abstract The World Health Organization predicts that by 2050, 2.1 billion people worldwide
will be over 60 years old, a drastic increase from only 1 billion in 2019. Considering these …

Experimental and computational investigation of the binding mechanism of thymol with human transferrin: Importance of dietary phytochemicals in Alzheimer's disease …

MS Khan, M Shahwan, S Anwar, DK Yadav… - Journal of Molecular …, 2023 - Elsevier
Transferrin (Tf) regulates free iron in the body, which is critical to shield the body from the
detrimental effects of free iron, a potent neurotoxin, in the aerobic surroundings of the blood …

Potential of flavonoids as anti-Alzheimer's agents: Bench to bedside

R Kaur, A Sood, DK Lang, S Bhatia… - … Science and Pollution …, 2022 - Springer
Developing therapies for neurodegenerative diseases are challenging because of the
presence of blood–brain barrier and Alzheimer being one of the commonest and uprising …