GPX4: The hub of lipid oxidation, ferroptosis, disease and treatment
Y Liu, Y Wan, Y Jiang, L Zhang, W Cheng - Biochimica et Biophysica Acta …, 2023 - Elsevier
Abstract Glutathione peroxidase 4 (GPx4) moonlights as structural protein and antioxidase
that powerfully inhibits lipid oxidation. In the past years, it is considered as a key regulator of …
that powerfully inhibits lipid oxidation. In the past years, it is considered as a key regulator of …
Lipid peroxidation and ferroptosis: The role of GSH and GPx4
F Ursini, M Maiorino - Free Radical Biology and Medicine, 2020 - Elsevier
Ferroptosis (FPT) is a form of cell death due to missed control of membrane lipid
peroxidation (LPO). According to the axiomatic definition of non-accidental cell death, LPO …
peroxidation (LPO). According to the axiomatic definition of non-accidental cell death, LPO …
Regulatory phenomena in the glutathione peroxidase superfamily
R Brigelius-Flohé, L Flohé - Antioxidants & redox signaling, 2020 - liebertpub.com
Significance: The selenium-containing Glutathione peroxidases (GPxs) 1–4 protect against
oxidative challenge, inhibit inflammation and oxidant-induced regulated cell death. Recent …
oxidative challenge, inhibit inflammation and oxidant-induced regulated cell death. Recent …
Lipid peroxidation-dependent cell death regulated by GPx4 and ferroptosis
H Imai, M Matsuoka, T Kumagai, T Sakamoto… - Apoptotic and Non …, 2017 - Springer
Glutathione peroxidase 4 (Phospholipid hydroperoxide glutathione peroxidase, PHGPx) can
directly reduce phospholipid hydroperoxide. Depletion of GPx4 induces lipid peroxidation …
directly reduce phospholipid hydroperoxide. Depletion of GPx4 induces lipid peroxidation …
[HTML][HTML] The metabolic underpinnings of ferroptosis
J Zheng, M Conrad - Cell metabolism, 2020 - cell.com
Acute or chronic cellular stress resulting from aberrant metabolic and biochemical processes
may trigger a pervasive non-apoptotic form of cell death, generally known as ferroptosis …
may trigger a pervasive non-apoptotic form of cell death, generally known as ferroptosis …
From selenium to selenoproteins: synthesis, identity, and their role in human health
The requirement of the trace element selenium for life and its beneficial role in human health
has been known for several decades. This is attributed to low molecular weight selenium …
has been known for several decades. This is attributed to low molecular weight selenium …
[HTML][HTML] An overview of ferroptosis in non-alcoholic fatty liver disease
S Wang, Z Liu, J Geng, L Li, X Feng - Biomedicine & Pharmacotherapy, 2022 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) is a public health problem associated with high
mortality and high morbidity rates worldwide. Presently, its complex pathophysiology is still …
mortality and high morbidity rates worldwide. Presently, its complex pathophysiology is still …
A white paper on phospholipid hydroperoxide glutathione peroxidase (GPx4) forty years later
The purification of a protein inhibiting lipid peroxidation led to the discovery of the
selenoperoxidase GPx4 forty years ago. Thus, the evidence of the enzymatic activity was …
selenoperoxidase GPx4 forty years ago. Thus, the evidence of the enzymatic activity was …
[HTML][HTML] Depletion of selenoprotein GPx4 in spermatocytes causes male infertility in mice
H Imai, N Hakkaku, R Iwamoto, J Suzuki… - Journal of Biological …, 2009 - ASBMB
Phospholipid hydroperoxide glutathione peroxidase (GPx4) is an intracellular antioxidant
enzyme that directly reduces peroxidized phospholipids. GPx4 is strongly expressed in the …
enzyme that directly reduces peroxidized phospholipids. GPx4 is strongly expressed in the …
Selenoproteins and maternal nutrition
Selenium (Se) is an essential trace element of fundamental importance to health due to its
antioxidant, anti-inflammatory and chemopreventive properties attributed to its presence …
antioxidant, anti-inflammatory and chemopreventive properties attributed to its presence …