Abstract Glutathione peroxidase 4 (GPx4) moonlights as structural protein and antioxidase
that powerfully inhibits lipid oxidation. In the past years, it is considered as a key regulator of …

Ferroptosis (FPT) is a form of cell death due to missed control of membrane lipid
peroxidation (LPO). According to the axiomatic definition of non-accidental cell death, LPO …

Significance: The selenium-containing Glutathione peroxidases (GPxs) 1–4 protect against
oxidative challenge, inhibit inflammation and oxidant-induced regulated cell death. Recent …

Glutathione peroxidase 4 (Phospholipid hydroperoxide glutathione peroxidase, PHGPx) can
directly reduce phospholipid hydroperoxide. Depletion of GPx4 induces lipid peroxidation …

Acute or chronic cellular stress resulting from aberrant metabolic and biochemical processes
may trigger a pervasive non-apoptotic form of cell death, generally known as ferroptosis …

The requirement of the trace element selenium for life and its beneficial role in human health
has been known for several decades. This is attributed to low molecular weight selenium …

Non-alcoholic fatty liver disease (NAFLD) is a public health problem associated with high
mortality and high morbidity rates worldwide. Presently, its complex pathophysiology is still …

The purification of a protein inhibiting lipid peroxidation led to the discovery of the
selenoperoxidase GPx4 forty years ago. Thus, the evidence of the enzymatic activity was …

Phospholipid hydroperoxide glutathione peroxidase (GPx4) is an intracellular antioxidant
enzyme that directly reduces peroxidized phospholipids. GPx4 is strongly expressed in the …

Selenium (Se) is an essential trace element of fundamental importance to health due to its
antioxidant, anti-inflammatory and chemopreventive properties attributed to its presence …